{
  "abstract": "Overweight and obesity in children are a major public health concern because of their short- and long-term metabolic, musculoskeletal, psychological and social consequences. In children, an increase in the prevalence of overweight was observed during the second half of the 20th century, including at very young ages, suggesting a role for factors acting very early in life. Among these early-life exposures, endocrine-disrupting chemicals (EDCs) may play an important role during the first 1,000 days, a critical window for metabolic programming. EDCs encompass a wide range of chemical compounds with diverse physicochemical properties and toxicokinetic profiles, and are generally classified into three major groups: persistent organic pollutants (POPs), some of which include per- and polyfluoroalkyl substances (PFAS); non-persistent pollutants, including phenols and phthalates, as well as certain pesticides; and trace elements (metals). Experimental data support the hypothesis that EDCs may affect adipogenesis, energy homeostasis and hormonal signalling, but human data are needed to confirm this hypothesis. Population-based mother–child cohorts provide a valuable tool for investigating these relationships in humans, despite some methodological challenges. Such studies have provided strong evidence of an association between organochlorine pesticides, particularly DDT/DDE and HCB, and BMI trajectories or the risk of obesity from early childhood through adolescence. In contrast, findings remain heterogeneous for PFAS, PCBs, phthalates, bisphenol A and its substitutes, parabens and other phenols, partly because of the temporal variability of exposure to non-persistent compounds and difficulties in exposure assessment. Evidence on metals, non-persistent pesticides and mixtures of contaminants remains limited and difficult to compare across studies. This review highlights the need for continued research in humans, based on sufficiently large cohort studies that enable accurate assessment of exposures during critical periods in relation to the potential early programming of subsequent metabolic trajectories.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "Manik Kadawathagedara"
    },
    {
      "name": "Marion Ouidir"
    },
    {
      "name": "Charline Warembourg"
    },
    {
      "name": "Barbara Heude"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9d6dwc0h51bw0.bib",
  "cited_by": 0,
  "doi": "10.1016/j.mmm.2026.09.013",
  "fulltext_url": null,
  "id": "9d6dwc0h51bw0",
  "issns": [
    "1957-2557"
  ],
  "landing_url": "https://hal.inrae.fr/hal-05778019v1",
  "language": "fr",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sde"
    ],
    [
      "openalex",
      "2307|Effects and risks of endocrine disrupting chemicals"
    ]
  ],
  "openalex": "W7214243947",
  "pdf_url": "https://hal.inrae.fr/hal-05778019/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-05",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/9d6dwc0h51bw0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:47Z",
      "native_id": "hal-05778019",
      "source": "hal",
      "url": "https://hal.inrae.fr/hal-05778019v1"
    }
  ],
  "subjects": [
    {
      "field": "earth",
      "origin": "hal:0.sde",
      "subfield": "environmental-science"
    }
  ],
  "title": "Exposition précoce aux perturbateurs endocriniens et développement du surpoids chez l’enfant et l’adolescent : enseignements des études épidémiologiques",
  "title_text": "Exposition précoce aux perturbateurs endocriniens et développement du surpoids chez l’enfant et l’adolescent : enseignements des études épidémiologiques",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:47Z",
  "url": "https://research.draconitic.com/paper/9d6dwc0h51bw0",
  "venue": "Médecine des Maladies Métaboliques",
  "versions": []
}