{
  "abstract": "Cadmium (Cd) is a persistent environmental heavy metal that bioaccumulates and is associated with diverse toxicities. Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent, and steatotic metabolic stress may increase vulnerability to toxicological insults. In this study, we used a free fatty acid (FFA)-treated hepatocyte model and high-fat diet (HFD)-fed steatotic mice to characterize hepatic responses to a short-term CdCl2 toxicological challenge under lipid overload conditions. In FFA-treated QSG-7701 cells, CdCl2 exposure was associated with increased lipid droplet accumulation, elevated oxidative stress, and increased apoptosis. In HFD-fed steatotic mice, short-term CdCl2 administration was associated with worsened liver injury and greater hepatic lipid accumulation compared with parallel steatotic controls. These phenotypic changes were accompanied by increased expression of lipogenesis-related markers, including SREBP-1c and SCD1, consistent with enhanced lipogenic signaling under steatotic stress. CdCl2 exposure was also associated with increased α-SMA and TGF-β, consistent with early fibrogenic activation in this short-term model rather than staged fibrosis. Rapamycin-treated mice exhibited attenuation of multiple injury- and lipid-related readouts compared with parallel CdCl2-treated groups, supporting its use as a pharmacological probe in this acute setting. Collectively, these observations support a model in which short-term CdCl2 challenge aggravates steatotic liver injury under lipid overload.",
  "abstract_shown": true,
  "affiliations": [
    "Guangzhou Medical University , , ,",
    "Capital Medical University , , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shuying Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yaqian Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Yuru Zong"
    },
    {
      "affs": [
        0
      ],
      "name": "Qibin Mai"
    },
    {
      "affs": [
        0
      ],
      "name": "Ruirui Qiu",
      "orcid": "0009-0007-8603-3231"
    },
    {
      "affs": [
        0
      ],
      "name": "Huidong Song"
    },
    {
      "affs": [
        1
      ],
      "name": "Hanqing Chen",
      "orcid": "0000-0001-5442-2071"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9dk58kdqcb6b4.bib",
  "cited_by": 0,
  "doi": "10.1021/acsomega.5c11799",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717757/?tool=EBI",
  "id": "9dk58kdqcb6b4",
  "issns": [
    "2470-1343"
  ],
  "landing_url": "https://pubs.acs.org/acsodf/article/11/42/64359/5449448/Cadmium-Exposure-Aggravates-SREBP-1c-Mediated",
  "language": "eng",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2307|Heavy Metal Exposure and Toxicity"
    ]
  ],
  "openalex": "W7221667737",
  "pdf_url": "https://pubs.acs.org/doi/pdf/10.1021/acsomega.5c11799",
  "pmcid": "PMC13717757",
  "pmid": "42959881",
  "published": "2026-10-13",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/9dk58kdqcb6b4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:39Z",
      "native_id": "10.1021/acsomega.5c11799",
      "source": "crossref",
      "url": "https://pubs.acs.org/acsodf/article/11/42/64359/5449448/Cadmium-Exposure-Aggravates-SREBP-1c-Mediated"
    },
    {
      "first_seen": "2026-10-31T00:20:37Z",
      "native_id": "PMC:PMC13717757",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13717757"
    },
    {
      "first_seen": "2026-11-01T00:20:52Z",
      "native_id": "MED:42959881",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42959881"
    },
    {
      "first_seen": "2026-11-02T12:22:01Z",
      "native_id": "PMC13717757",
      "source": "pmc",
      "url": "https://doi.org/10.1021/acsomega.5c11799"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2307|Heavy Metal Exposure and Toxicity",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Cadmium Exposure Aggravates SREBP-1c-Mediated Hepatic Steatosis and Liver Injury in High-Fat Diet-Fed Mice",
  "title_text": "Cadmium Exposure Aggravates SREBP-1c-Mediated Hepatic Steatosis and Liver Injury in High-Fat Diet-Fed Mice",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:01Z",
  "url": "https://research.draconitic.com/paper/9dk58kdqcb6b4",
  "venue": "ACS Omega",
  "versions": []
}