{
  "abstract": "Salivary gland (SG) hypofunction significantly affects the life quality of patients with hyposalivation. Current treatment options for these conditions are limited and often result in undesirable side effects. To address this issue, we've developed a developmentally inspired strategy to derive salivary gland epithelial progenitor (SGEP) cells from human pluripotent stem cells (PSC). Then we employ SGEP cells derived from human PSC with a SOX10::GFP reporter to engineer three-dimensional lumenized SG organoids, with well-defined lumens and secretory function, reminiscent of human salivary glands. Upon transplantation into the submandibular gland of athymic nude mice, mCherry+ salivary gland organoids (SGO) integrate into the gland and differentiated into salivary gland phenotypes, including acinar, ductal and myoepithelial structures. Our findings suggest that SG organoids may hold promise for studying SG development, disease progression and drug screening, as well as for development of cell therapies for salivary gland regeneration.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY, USA.",
    "Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, USA.",
    "Bond Life Sciences Center, University of Missouri, Columbia, MO, USA.",
    "Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Missouri, Columbia, MO, USA.",
    "Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.",
    "Department of Biochemistry, University of Missouri, Columbia, MO, USA.",
    "Department of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY, USA. sandread@buffalo.edu.",
    "Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, USA. sandread@buffalo.edu.",
    "New York State Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY, USA. sandread@buffalo.edu.",
    "Center of Cell, Gene and Tissue Engineering, University at Buffalo, The State University of New York, Buffalo, NY, USA. sandread@buffalo.edu."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Laura J Sherwood"
    },
    {
      "affs": [
        1
      ],
      "name": "Ronel Z Samuel",
      "orcid": "0009-0005-0164-2114"
    },
    {
      "affs": [
        1
      ],
      "name": "Sai Harsha Bhamidipati",
      "orcid": "0009-0004-7671-0954"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Kihoon Nam"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Frank Maslow"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Travis Small"
    },
    {
      "affs": [
        4
      ],
      "name": "Yali Zhang"
    },
    {
      "affs": [
        4
      ],
      "name": "Jianmin Wang",
      "orcid": "0000-0001-7527-0409"
    },
    {
      "affs": [
        4
      ],
      "name": "Song Liu"
    },
    {
      "affs": [
        2,
        3,
        5
      ],
      "name": "Olga J Baker",
      "orcid": "0000-0002-0628-8645"
    },
    {
      "affs": [
        6,
        7,
        8,
        9
      ],
      "name": "Stelios T Andreadis",
      "orcid": "0000-0001-9885-0457"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9dz1knbc7v6fy.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-77724-5",
  "fulltext_url": "https://europepmc.org/articles/PMC13680624",
  "id": "9dz1knbc7v6fy",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://europepmc.org/article/MED/42897156",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Pluripotent Stem Cells Research"
    ]
  ],
  "openalex": "W7213451287",
  "pdf_url": "https://europepmc.org/articles/PMC13680624?pdf=render",
  "pmcid": "PMC13680624",
  "pmid": "42897156",
  "published": "2026-09-17",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9dz1knbc7v6fy.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:41Z",
      "native_id": "MED:42897156",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42897156"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Pluripotent Stem Cells Research",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Development-inspired approach for the derivation of functional and transplantable salivary gland organoids from human pluripotent stem cells.",
  "title_text": "Development-inspired approach for the derivation of functional and transplantable salivary gland organoids from human pluripotent stem cells.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:41Z",
  "url": "https://research.draconitic.com/paper/9dz1knbc7v6fy",
  "venue": "Nature communications",
  "versions": []
}