{
  "abstract": "Background: This pilot study evaluated changes in eating behavior, appetite, and dietary habits during semaglutide or tirzepatide treatment in adults with obesity. Methods: In this prospective observational study, 38 non-diabetic adults with obesity (mean age 56.1 ± 11.3 years; 73.7% female; BMI 32.7 ± 4.5 kg/m2) initiating semaglutide (n = 21) or tirzepatide (n = 17) were assessed at baseline and after 3 months. Clinical parameters and self-reported eating behaviors were evaluated using standardized measurements and a study-specific questionnaire. Results: Mean body weight decreased by 7.2 ± 4.9 kg (p < 0.001), and systolic blood pressure decreased by 6.1 ± 6.3 mm Hg (p < 0.001). Cravings for sweet and savory foods, difficulty resisting hunger between meals, and daily meal frequency decreased, whereas perceived meal-induced satiety increased (all p ≤ 0.005). A substantial reduction in meal portion size was reported by 84.2% of participants. Reported food-group consumption changed, but improved overall dietary quality was not established. Conclusions: Over 3 months, incretin-based treatment was accompanied by weight loss and changes in self-reported eating behavior. The observational design, absence of a control group, and unvalidated questionnaire limit interpretation. Larger controlled studies using validated measures are warranted.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Open University, Via di Val Cannuta, 247, 00166 Rome, Italy",
    "Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Roma, Via di Val Cannuta, 247, 00166 Rome, Italy",
    "Campus Bio-Medico University of Rome, 00128 Rome, Italy",
    "Biochemical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London E1 4NS, UK"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Elisabetta Camajani",
      "orcid": "0000-0002-1866-8223"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Francesco Frigerio",
      "orcid": "0000-0002-9502-3314"
    },
    {
      "affs": [
        0
      ],
      "name": "Chiara Quattrini"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Valentina Franzese"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Andrea Armani",
      "orcid": "0000-0002-2130-1596"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Stefania Gorini",
      "orcid": "0000-0003-4182-9942"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Tiziana Filardi",
      "orcid": "0000-0001-5002-0753"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Alessandra Feraco"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Massimiliano Caprio",
      "orcid": "0000-0003-0722-7163"
    },
    {
      "affs": [
        0
      ],
      "name": "Mauro Lombardo",
      "orcid": "0000-0001-7509-5487"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9eacp3nhrg41k.bib",
  "cited_by": 0,
  "doi": "10.3390/nu18213675",
  "fulltext_url": null,
  "id": "9eacp3nhrg41k",
  "issns": [
    "2072-6643"
  ],
  "landing_url": "https://www.mdpi.com/2072-6643/18/21/3675",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-05",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/9eacp3nhrg41k.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T00:21:24Z",
      "native_id": "10.3390/nu18213675",
      "source": "crossref",
      "url": "https://www.mdpi.com/2072-6643/18/21/3675"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:2072-6643",
      "subfield": "nutrition"
    }
  ],
  "title": "Changes in Eating Behavior and Food Preferences After Semaglutide or Tirzepatide Initiation: A Prospective Observational Pilot Study",
  "title_text": "Changes in Eating Behavior and Food Preferences After Semaglutide or Tirzepatide Initiation: A Prospective Observational Pilot Study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T00:21:23Z",
  "url": "https://research.draconitic.com/paper/9eacp3nhrg41k",
  "venue": "Nutrients",
  "versions": []
}