{
  "abstract": "Objectives: To evaluate the proof-of-concept feasibility of identifying individuals at high risk of cardiovascular disease through community-based PocDoc Healthy Heart point-of-care screening in a large, ethnically diverse, disadvantaged real-world cohort in the United Kingdom. Methods: Proof-of-concept, non-randomised, non-interventional real-world cardiovascular disease risk case finding study in adults aged 18 years or older in real-world communities across the United Kingdom. Main outcome measures were identification of individuals with high risk of cardiovascular disease, defined as QRISK3 score ≥10%; and individuals meeting the criteria for weight loss, smoking cessation, or hypertension management services. Results: A total of 4,256 individuals (mean age 49 years, 57% male, 31% body mass index ≥30 kg/m2) were included in the Primary Cohort. The Targeted Outreach and Workplace sub-cohorts comprised 1,970 and 756 individuals, respectively. In the Primary Cohort, 35% (1,486/4,256) had high (>5.0 mmol/L) total serum cholesterol, 10% were smokers, 10% met criteria for weight loss services and 19% met criteria for hypertension management services. QRISK3 scores were generated for individuals who had not previously had a cardiovascular disease event (~90% of screened individuals). A QRISK3 score ≥10% was found in 20% (784/3,842) of individuals in the Primary Cohort, 26% (457/1,743) in the Targeted Outreach sub-cohort, and 6% (41/701) in the Workplace sub-cohort. In the Primary Cohort, 60% (472/784) of individuals with a QRISK3 score ≥10% were not being treated with a lipid-lowering therapy at the time of testing. Conclusions: In this proof-of-concept study, community-based point-of-care screening identified individuals with elevated cardiovascular risk and unmet cardiovascular risk management needs. These findings are hypothesis-generating and provide the rationale for further controlled studies with systematic follow-up and health-economic analyses to evaluate whether this approach can deliver improved clinical and system-level outcomes. Trial registration: ClinicalTrials.gov NCT06258005",
  "abstract_shown": true,
  "affiliations": [
    "PocDoc, Vital Signs Solutions Ltd, Cambridge, United Kingdom",
    "Health Innovation North East and North Cumbria, Newcastle upon Tyne, United Kingdom",
    "Howbeck Healthcare, Cheshire, United Kingdom"
  ],
  "article_type": "Research Article",
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  "author_total": 10,
  "authors": [
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      "name": "Kiran Roest"
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      "name": "Catherine Kelly"
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    {
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      "name": "Tracy Marshall"
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    {
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    },
    {
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    },
    {
      "name": "Rachel Hatfield"
    },
    {
      "name": "Kate Bunyan"
    },
    {
      "name": "Luke Dawson"
    },
    {
      "name": "Steve Roest"
    },
    {
      "name": "Julia Newton"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9eefp0m9sjfn6.bib",
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  "doi": "10.1371/journal.pone.0358999",
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  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
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  "native_subjects": [
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      "/Biology and life sciences/Anatomy/Cardiovascular anatomy/Heart"
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      "/Medicine and health sciences/Medical conditions/Cardiovascular diseases"
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      "/Medicine and health sciences/Medical conditions/Cardiovascular diseases/Cardiovascular disease risk"
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  "pdf_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0358999&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-29",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/9eefp0m9sjfn6.ris",
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    {
      "first_seen": "2026-10-30T12:17:37Z",
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  "subjects": [
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      "subfield": "cardiovascular"
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  "title": "Rapid community \"Healthy Heart\" screening to identify people at high risk of cardiovascular events",
  "title_text": "Rapid community \"Healthy Heart\" screening to identify people at high risk of cardiovascular events",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:37Z",
  "url": "https://research.draconitic.com/paper/9eefp0m9sjfn6",
  "venue": "PLOS One",
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}