{
  "abstract": "Background: Patients with brain tumors involving the SMA often develop postoperatively a mostly transient contralateral akinesia (‘SMA-syndrome'), which may primarily be a cognitive disorder of executive functions. However, the neurophysiological correlates are unclear. Considering the SMA as a gateway between motor and cognitive control functions, we explored structural SMA-connectivity (SC), and functional connectivity (FC) of the sensorimotor (SMN), and of cognitive networks in SMA-tumor patients.\n\nMethods: 13 SMA-tumor patients and 13 matched healthy controls underwent diffusion-tensor-imaging (DTI) and resting-state-fMRI preoperatively. Intra- (Frontal Aslant Tract) and interhemispheric SC of the SMA (SMA-SMA, SMA-M1) was compared between groups. FC-networks were established by group Independent Component Analysis (ICA), and subjected to a second-level ROI-to-ROI (region-of-interest) analysis to investigate between-group differences.\n\nResults: DTI revealed microstructural white-matter disintegration and smaller tract volumes of SMA-M1 connectivity ( p < 0.005), and by trend of the FAT ( p < 0.06), with differing SMA-M1 fiber-length in patients ( p < 0.026). SMA-SMA SC was not reduced, but showed greater variance in patients. While FC was significantly decreased within different cognitive networks, FC was increased within the SMN, as well as between the SMA and the contralesional frontoparietal network ( p < 0.046) in patients.\n\nConclusions: In this exploratory study, we found sensorimotor- as well as large-scale cognitive network alterations prior to therapeutic intervention, suggesting tumor-associated SC disintegration to be accompanied by in- and decreases of FC within and across different networks. Future studies incorporating neuropsychological-testing are required to characterize pretherapeutic connectivity alterations with regard to their behavioral significance, and to determine whether they may impact the postoperative functional outcome.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurosurgery, RWTH Aachen University",
    "Center for Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf (CIO ABCD)",
    "Brain Imaging Facility, Interdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University",
    "Department of Diagnostic and Interventional Neuroradiology, RWTH Aachen University",
    "Department of Neurosurgery, University of Erlangen"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Chuh-Hyoun Na"
    },
    {
      "affs": [
        2
      ],
      "name": "Rik Sijben"
    },
    {
      "affs": [
        2
      ],
      "name": "Oleg Posnansky"
    },
    {
      "affs": [
        3
      ],
      "name": "Martin Wiesmann"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hans Clusmann"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Daniel Delev"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Rea Rodriguez-Raecke"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9eg4jt589z9cg.bib",
  "cited_by": 0,
  "doi": "10.3389/fneur.2026.1878278",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13732028/",
  "id": "9eg4jt589z9cg",
  "issns": [
    "1664-2295"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1878278/full",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2805|Functional Brain Connectivity Studies"
    ]
  ],
  "openalex": "W7223085514",
  "pdf_url": "https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1878278/pdf",
  "pmcid": "PMC13732028",
  "pmid": "42985189",
  "published": "2026-10-21",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/9eg4jt589z9cg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:16Z",
      "native_id": "10.3389/fneur.2026.1878278",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1878278/full"
    },
    {
      "first_seen": "2026-11-08T12:22:05Z",
      "native_id": "PMC13732028",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fneur.2026.1878278"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2805|Functional Brain Connectivity Studies",
      "subfield": "neuroscience"
    }
  ],
  "title": "Tumor lesions in the supplementary motor area may induce large-scale sensorimotor and cognitive network alterations— A functional and structural connectivity analysis",
  "title_text": "Tumor lesions in the supplementary motor area may induce large-scale sensorimotor and cognitive network alterations— A functional and structural connectivity analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:22:05Z",
  "url": "https://research.draconitic.com/paper/9eg4jt589z9cg",
  "venue": "Frontiers in Neurology",
  "versions": []
}