{
  "abstract": "Objectives: We aimed to evaluate the performance of the age-adapted Pediatric Sequential Organ Failure Assessment (pSOFA) score, as a predictor of mortality in patients admitted to pediatric intensive care units (PICUs), and to compare it with the Pediatric Risk of Mortality 4 (PRISM 4) and Pediatric Index of Mortality 3 (PIM 3) scores. Methods: This single-center, retrospective study analyzed data from 1440 eligible PICU admissions to a tertiary PICU. The pSOFA, PRISM 4, and PIM 3 scores were calculated retrospectively for each patient. Results: The overall mortality was 13.1%, and the median length of stay was 11 days. The median (IQR) pSOFA score was significantly higher in non-survivors than in survivors [6 (4-10) vs. 3 (2-4), p < 0.001]. Mortality increased significantly with increasing pSOFA scores (p < 0.001). The area under the receiver operating characteristic curve (AUC) values for pSOFA, PRISM 4, and PIM 3 were 0.807, 0.847, and 0.781, respectively. The pSOFA score exhibited a significant positive correlation with both PRISM 4 and PIM 3 (p < 0.001). PRISM 4 and PIM 3 demonstrated evidence of miscalibration in this cohort, with observed mortality exceeding mean predicted mortality for both models. Conclusions: pSOFA demonstrated good discrimination for PICU mortality and a strong association with mortality in this single-center retrospective cohort. PRISM 4 showed significantly greater discrimination than pSOFA, whereas pSOFA and PIM 3 did not differ significantly. These findings support further prospective multicenter evaluation before broader clinical implementation.",
  "abstract_shown": true,
  "affiliations": [
    "Pediatric Intensive Care Unit, Bezmialem Vakif University, Fatih, Istanbul 34093, Turkey.",
    "Research and New Technology Department, Hamilton Medical AG, 7402 Bonaduz, Switzerland.",
    "Pediatric Intensive Care Unit, Dr. Behcet Uz Children's Hospital, University of Health Sciences, Izmir 35210, Turkey.",
    "Pediatric Intensive Care Unit, Acibadem Altunizade Hospital, Acibadem University, Istanbul 34662, Turkey.",
    "Pediatric Intensive Care Unit, Cam Sakura Research and Training Hospital, University of Health Sciences, Istanbul 34480, Turkey.",
    "Pediatric Intensive Care Unit, Aydin Maternity and Children's Hospital, Aydın 09020, Turkey.",
    "Division of Otolaryngology, Department of Surgery, Denver Health Medical Center, Denver, CO 80204, USA.",
    "Neuroscience Doctoral Program, Yeditepe University, Istanbul 34755, Turkey."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ferhat Sarı",
      "orcid": "0000-0002-9134-767X"
    },
    {
      "affs": [
        1
      ],
      "name": "Gokhan Ceylan",
      "orcid": "0000-0002-1730-6968"
    },
    {
      "affs": [
        2
      ],
      "name": "Ozlem Sarac"
    },
    {
      "affs": [
        2
      ],
      "name": "Gulhan Atakul"
    },
    {
      "affs": [
        3
      ],
      "name": "Sevgi Topal"
    },
    {
      "affs": [
        4
      ],
      "name": "Mustafa Colak"
    },
    {
      "affs": [
        5
      ],
      "name": "Ekin Soydan",
      "orcid": "0000-0003-2626-5499"
    },
    {
      "affs": [
        2
      ],
      "name": "Hasan Agin"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Aynur Aliyeva",
      "orcid": "0000-0001-9398-4261"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9ejc5r7jjv8sg.bib",
  "cited_by": 0,
  "doi": "10.3390/healthcare14193162",
  "fulltext_url": "https://europepmc.org/articles/PMC13664861",
  "id": "9ejc5r7jjv8sg",
  "issns": [
    "2227-9032"
  ],
  "landing_url": "https://europepmc.org/article/MED/42881601",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Sepsis Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7214157218",
  "pdf_url": "https://europepmc.org/articles/PMC13664861?pdf=render",
  "pmcid": "PMC13664861",
  "pmid": "42881601",
  "published": "2026-09-24",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9ejc5r7jjv8sg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42881601",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42881601"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Sepsis Diagnosis and Treatment",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Evaluation of the pSOFA Score in a Pediatric Intensive Care Unit and Its Discriminative Performance Compared with PRISM 4 and PIM 3.",
  "title_text": "Evaluation of the pSOFA Score in a Pediatric Intensive Care Unit and Its Discriminative Performance Compared with PRISM 4 and PIM 3.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/9ejc5r7jjv8sg",
  "venue": "Healthcare (Basel, Switzerland)",
  "versions": []
}