{
  "abstract": "While conventional radical fluoroalkylation typically requires exogenous catalysts or photoactivation to overcome significant kinetic barriers, here we report bench-stable μ-oxo-bridged iodine(III) reagents that release fluoro(halo)methyl radicals upon heating without an external catalyst, additive, or light. The resulting radicals initiate cascade cyclizations of methacrylamides and methacrylohydrazides to afford fluorinated oxindoles, pyrazolones, and related heterocycles. Variation of the fluorinated carboxylate ligand within the iodine(III) reagent framework controls the identity of the transferred C1 fragment, thereby providing chlorofluoromethyl, bromofluoromethyl, difluoromethyl, and monofluoromethyl products from a common reagent architecture. The transformation is compatible with structurally diverse and natural-product-derived substrates and proceeds efficiently upon scale-up. By encoding the required bond lability directly into the iodine(III) framework, this strategy establishes a general platform for the catalyst-, additive-, and light-free generation and incorporation of fluorinated C1 radicals into complex molecular frameworks.",
  "abstract_shown": true,
  "affiliations": [
    "National Institute of Research and Innovation",
    "Institute of Solid State Physics",
    "University of Latvia"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Anupam Das"
    },
    {
      "affs": [
        0
      ],
      "name": "Nagarajan Ramkumar"
    },
    {
      "affs": [
        0
      ],
      "name": "Artis Kinēns"
    },
    {
      "affs": [
        0
      ],
      "name": "Sergey Belyakov"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Andris Antuzevičs"
    },
    {
      "affs": [
        0
      ],
      "name": "Janis Veliks",
      "orcid": "0000-0003-0955-8257"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9emj9ghah8e3c.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15009392/v1",
  "fulltext_url": null,
  "id": "9emj9ghah8e3c",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009392/v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "3003|Fluorine in Organic Chemistry"
    ]
  ],
  "openalex": "W7214237290",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009392/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-23",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/9emj9ghah8e3c.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:21Z",
      "native_id": "10.26434/chemrxiv.15009392",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009392/v2"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3003|Fluorine in Organic Chemistry",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "μ-Oxo-Bridged Iodine(III) Reagents Enable Catalyst- and Light-Free Fluoro(halo)methyl Radical Generation",
  "title_text": "μ-Oxo-Bridged Iodine(III) Reagents Enable Catalyst- and Light-Free Fluoro(halo)methyl Radical Generation",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:22Z",
  "url": "https://research.draconitic.com/paper/9emj9ghah8e3c",
  "venue": "ChemRxiv",
  "versions": []
}