{
  "abstract": "RNAactDrug 2.0 (available at https://bio-bigdata.hrbmu.edu.cn/RNAactDrug or https://bio-datamining.hrbmu.edu.cn/RNAactDrug) is an updated resource for systematically exploring molecular features associated with drug sensitivity across multi-omics datasets. We have updated the RNAactDrug 2.0 database with significantly expanded data and improved features, including (i) ∼30 000 drugs, 38 908 RNA molecules, and 22 800 375 drug–RNA associations from large-scale pharmacogenomic databases, covering four molecular layers: expression, copy number variation (CNV), mutation, and methylation; (ii) 11 099 cases from The Cancer Genome Atlas across 33 cancer types are integrated to support clinical and pan-cancer analyses of drug sensitivity-associated RNA features; (iii) ∼3.8 million cells from >200 single-cell RNA sequencing datasets, spanning 34 cancer types and 38 tissues, enable analysis of cell type-specific patterns and intratumoral heterogeneity; (iv) 26 440 enhancers and 788 444 drug-enhancer associations, combined with potential target prediction, provide an exploratory epigenetic regulatory dimension; (v) enhanced search and browsing functionalities, together with seven tools for functional annotation, pan-cancer analysis, tumor microenvironment profiling, single-cell trajectory and CNV analysis, and enhancer-related analyses. In summary, RNAactDrug 2.0 is a crucial resource for the multi-omics dissection of drug sensitivity-associated molecules, providing important support for the discovery of drug resistance biomarkers and the advancement of personalized therapeutic strategies.",
  "abstract_shown": true,
  "affiliations": [
    "College of Bioinformatics Science and Technology, Harbin Medical University , 157 Baojian Road, Harbin 150081 ,"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Feng Li",
      "orcid": "0009-0008-9589-9149"
    },
    {
      "affs": [
        0
      ],
      "name": "Liying Pei"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiangtao Xing"
    },
    {
      "affs": [
        0
      ],
      "name": "Anhui Kang"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhe Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Wensong Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Siyao Lu"
    },
    {
      "affs": [
        0
      ],
      "name": "Longqi Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinyi Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Chunlong Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yanjun Xu",
      "orcid": "0000-0002-6552-4476"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9ew2v2wg2rqac.bib",
  "cited_by": 0,
  "doi": "10.1093/nar/gkag1117",
  "fulltext_url": null,
  "id": "9ew2v2wg2rqac",
  "issns": [
    "0305-1048",
    "1362-4962"
  ],
  "landing_url": "https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkag1117/9006193",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": "https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkag1117/72735020/gkag1117.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-02",
  "publisher": "Oxford University Press (OUP)",
  "ris": "https://research.draconitic.com/paper/9ew2v2wg2rqac.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T12:22:55Z",
      "native_id": "10.1093/nar/gkag1117",
      "source": "crossref",
      "url": "https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkag1117/9006193"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "issn:0305-1048",
      "subfield": "molecular-biology"
    }
  ],
  "title": "RNAactDrug 2.0: an updated resource for systematically exploring molecular features associated with drug sensitivity across multi-omics datasets",
  "title_text": "RNAactDrug 2.0: an updated resource for systematically exploring molecular features associated with drug sensitivity across multi-omics datasets",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T00:24:33Z",
  "url": "https://research.draconitic.com/paper/9ew2v2wg2rqac",
  "venue": "Nucleic Acids Research",
  "versions": []
}