{
  "abstract": "Purpose: To investigate the sex-related differences in postoperative complications following pelvic exenteration.\n\nMethods: This retrospective subanalysis used a multicenter registry of patients who underwent pelvic exenteration for locally advanced or recurrent rectal cancer. We included 218 patients (177 men and 41 women) in this study. The sex-related differences in postoperative complications were evaluated, and sex-by-factor interactions were assessed using logistic regression models, including sex, each perioperative factor, and the corresponding interaction term.\n\nResults: A significant sex-by-surgical approach interaction was observed for Clavien–Dindo Grade II or higher complications (pinteraction < 0.01). In open surgery, Grade II or higher complications occurred in 82.7% (43/52) of men compared with 38.5% (5/13) of women, whereas no clear sex difference was observed in minimally invasive surgery (69.6% [87/125] vs. 75.0% [21/28]). No significant sex-by-surgical approach interaction was detected for grade III or higher complications. Conversely, a significant sex-by-operative time interaction was observed, which was not apparent for Grade II complications.\n\nConclusion: Sex-related differences in postoperative complications after pelvic exenteration were not uniform but emerged with increased surgical invasiveness. Therefore, sex may affect the postoperative risk under conditions of increased surgical stress.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s00595-026-03415-9.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Lower GI, Department of Gastroenterological Surgery, Hyogo Medical University, 1-1, Mukogawa, Nishinomiya, 663-8501 Hyogo Japan",
    "Department of Biostatistics, Hyogo Medical University, Nishinomiya, Hyogo Japan",
    "Department of Gastrointestinal Surgery, Institute of Science Tokyo, Tokyo, Japan",
    "Division of Inflammatory Bowel Disease Surgery, Department of Gastroenterological Surgery, Hyogo Medical University, Nishinomiya, Japan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Kei Kimura"
    },
    {
      "affs": [
        1
      ],
      "name": "Masataka Igeta"
    },
    {
      "affs": [
        2
      ],
      "name": "Yusuke Yatabe"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuko Fukumoto"
    },
    {
      "affs": [
        0
      ],
      "name": "Kazuma Ito"
    },
    {
      "affs": [
        0
      ],
      "name": "Ayako Imada"
    },
    {
      "affs": [
        0
      ],
      "name": "Jihyung Song"
    },
    {
      "affs": [
        3
      ],
      "name": "Ryuichi Kuwahara"
    },
    {
      "affs": [
        3
      ],
      "name": "Yuki Horio"
    },
    {
      "affs": [
        3
      ],
      "name": "Motoi Uchino"
    },
    {
      "affs": [
        3
      ],
      "name": "Yusuke Kinugasa"
    },
    {
      "affs": [
        0
      ],
      "name": "Masataka Ikeda"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9f6zaan03bq5c.bib",
  "cited_by": 0,
  "doi": "10.1007/s00595-026-03415-9",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13722729/",
  "id": "9f6zaan03bq5c",
  "issns": [
    "0941-1291",
    "1436-2813"
  ],
  "landing_url": "https://doi.org/10.1007/s00595-026-03415-9",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2730|Colorectal Cancer Surgical Treatments"
    ]
  ],
  "openalex": "W7168377403",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s00595-026-03415-9.pdf",
  "pmcid": "PMC13722729",
  "pmid": "42455157",
  "published": "2026-07-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9f6zaan03bq5c.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:30Z",
      "native_id": "PMC13722729",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s00595-026-03415-9"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Colorectal Cancer Surgical Treatments",
      "subfield": "oncology"
    }
  ],
  "title": "Sex-related differences in postoperative complications after pelvic exenteration and their relationship with surgical invasiveness in a multicenter study",
  "title_text": "Sex-related differences in postoperative complications after pelvic exenteration and their relationship with surgical invasiveness in a multicenter study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:30Z",
  "url": "https://research.draconitic.com/paper/9f6zaan03bq5c",
  "venue": "Surgery Today",
  "versions": []
}