{
  "abstract": "目的本研究基于网络药理学策略，系统筛选并构建百秋李醇抗脑胶质瘤的核心作用靶点及信号通路网络，深入解析其多靶点、多通路干预脑胶质瘤的潜在分子机制。方法通过 TCMSP、PharmMapper 数据库获取百秋李醇潜在作用靶点；采用 OMIM、Genecards 数据库检索并整合脑胶质瘤疾病相关靶点；取两者交集获得百秋李醇-脑胶质瘤共同靶点。借助 STRING 数据库构建蛋白相互作用网络（PPI），利用 Cytoscape 3.7.2软件进行可视化分析。基于 R3.6.0 软件及 Bioconductor 工具包，对共同靶点进行基因本体（GO）功能富集分析与京都基因与基因组百科全书（KEGG）通路富集分析。结果共筛选得到百秋李醇-脑胶质瘤共同靶点 41 个。通路富集结果显示，百秋李醇可调控多条与脑胶质瘤恶性进展密切相关的信号通路，其中以 PI3K-Akt、MAPK、Ras 等经典肿瘤通路最为显著。结论百秋李醇具有多靶点、多通路协同作用特点，同一靶点可参与多项生物学过程及多条信号通路调控。其抗脑胶质瘤效应可能主要通过调控 PI3K-Akt、MAPK、Ras 等关键通路实现，为后续实验研究与临床转化提供理论依据。",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "单卓越"
    },
    {
      "name": "贾茗博"
    },
    {
      "name": "王欣"
    },
    {
      "name": "赵丽艳"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9fjtshx4pcxxr.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.018",
  "id": "9fjtshx4pcxxr",
  "issns": [
    "1007-4287"
  ],
  "landing_url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.018",
  "language": "zh",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RB1-214"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-24",
  "publisher": "Editorial Office of Chinese Journal of Laboratory Diagnosis",
  "ris": "https://research.draconitic.com/paper/9fjtshx4pcxxr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:45Z",
      "native_id": "6c8651cd9eef46cfa64b6c3443d41c01",
      "source": "doaj",
      "url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.018"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RB1-214",
      "subfield": "general"
    }
  ],
  "title": "基于网络药理学探讨百秋李醇抗脑胶质瘤机制",
  "title_text": "基于网络药理学探讨百秋李醇抗脑胶质瘤机制",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:45Z",
  "url": "https://research.draconitic.com/paper/9fjtshx4pcxxr",
  "venue": "Zhongguo shiyan zhenduanxue",
  "versions": []
}