{
  "abstract": "Background Amateur marathon runners (AMRs) engage in long‐term endurance training in non‐professional contexts, yet the intrinsic brain functional organization associated with amateur marathon training remains unclear. This study examined resting‐state functional alterations in AMRs using regional homogeneity (ReHo), amplitude of low‐frequency fluctuations (ALFF), and seed‐based functional connectivity (FC). Methods Sixty‐two AMRs and 42 healthy controls (HCs) underwent resting‐state fMRI. Group differences in mean ReHo (mReHo) and mean ALFF (mALFF) were first examined, followed by seed‐based FC analyses. Within the AMR group, partial correlation and exploratory voxel‐wise correlation analyses were performed to assess associations between imaging measures and behavioral and running‐related variables. Results AMRs showed increased mReHo in the left cerebellar lobule VI extending to the lingual gyrus and in the right lingual gyrus, and decreased mReHo in the medial orbitofrontal cortex. They also showed decreased mALFF in the right insula and increased mALFF in the left precuneus extending to the paracentral lobule. Seed‐based FC analyses revealed stronger FC involving medial orbitofrontal‐insula/superior temporal and medial orbitofrontal‐supplementary motor circuits, right lingual‐occipital/cerebellar visual regions, and right insula‐inferior frontal/striatal regions. Within the AMR group, right insula mALFF was positively associated with weekly running volume, while exploratory voxel‐wise analyses additionally identified associations involving the left calcarine cortex, left fusiform gyrus, and left cerebellar Crus I. Conclusions AMRs showed distributed resting‐state functional alterations involving visual‐cerebellar, insular, motor‐control, and higher‐order regulatory systems. Given the cross‐sectional design, these findings should be interpreted as associations rather than evidence of training‐induced neural adaptation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology Traditional Chinese and Western Medicine Hospital of Wuhan Tongji Medical College Huazhong University of Science and Technology Wuhan People's Republic of China",
    "Department of Radiology Renmin Hospital of Wuhan University Wuhan People's Republic of China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Fangliang Guo"
    },
    {
      "affs": [
        0
      ],
      "name": "Houjie Ni"
    },
    {
      "affs": [
        0
      ],
      "name": "Minghui Zhu"
    },
    {
      "affs": [
        1
      ],
      "name": "Yushuang Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Yilin Zhao"
    },
    {
      "affs": [
        1
      ],
      "name": "Yawen Ao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9fp1vwnv3y0bf.bib",
  "cited_by": 0,
  "doi": "10.1002/brb3.71908",
  "fulltext_url": "https://doi.org/10.1002/brb3.71908",
  "id": "9fp1vwnv3y0bf",
  "issns": [
    "2162-3279"
  ],
  "landing_url": "https://doi.org/10.1002/brb3.71908",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC321-571"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-10",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/9fp1vwnv3y0bf.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T14:21:40Z",
      "native_id": "0d251277833c441faef06a34d93fe3a2",
      "source": "doaj",
      "url": "https://doi.org/10.1002/brb3.71908"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RC321-571",
      "subfield": "general"
    }
  ],
  "title": "Resting‐State Functional Alterations Associated With Endurance Training in Amateur Marathon Runners",
  "title_text": "Resting‐State Functional Alterations Associated With Endurance Training in Amateur Marathon Runners",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T14:21:40Z",
  "url": "https://research.draconitic.com/paper/9fp1vwnv3y0bf",
  "venue": "Brain and Behavior",
  "versions": []
}