{
  "abstract": "INTRODUCTION: If mild cognitive impairment (MCI) is diagnosed after dementia, it suggests either the dementia diagnosis was premature, or the MCI diagnosis is incorrect. We investigated the prevalence and predictors of such “diagnostic reversion”—MCI after dementia—in a large health system.\n\nMETHODS: Among 5965 patients aged 50+ with incident dementia in University of California San Francisco electronic health records, we identified “reverters” with a subsequent MCI diagnosis. We used group least absolute shrinkage and selection operator–regularized logistic regression and random forest models to identify predictors.\n\nRESULTS: Reversion occurred in 13.7% of patients. Lower odds were observed among older adults (odds ratio [OR] = 0.95/year; 95% confidence interval [CI]: 0.92–0.98), while higher odds were found among Spanish speakers (OR = 2.26; 95% CI: 1.28–4.00), those with greater cardiovascular risk (OR = 1.16; 95% CI: 1.01–1.33), and higher Charlson Comorbidity Index burden (OR = 1.09; 95% CI: 1.05–1.14).\n\nDISCUSSION: Diagnostic reversion is common and socially patterned, suggesting contributions from misdiagnosis, clinical uncertainty, or variability in clinical presentation and care setting.",
  "abstract_shown": true,
  "affiliations": [
    "Bakar Computational Health Sciences Institute University of California, San Francisco San Francisco California USA",
    "Department of Epidemiology Boston University School of Public Health Boston Massachusetts USA",
    "Department of Epidemiology and Biostatistics University of California, San Francisco San Francisco California USA",
    "Academic Research Services University of California San Francisco California USA",
    "Department of Pediatrics and Medicine University of California, San Francisco San Francisco California USA",
    "Global Brain Health Institute University of California, San Francisco San Francisco California USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Silvia Miramontes",
      "orcid": "0000-0001-5805-0500"
    },
    {
      "affs": [
        0
      ],
      "name": "Umair Khan"
    },
    {
      "affs": [
        1
      ],
      "name": "Scott Zimmerman"
    },
    {
      "affs": [
        2
      ],
      "name": "Erin L. Ferguson"
    },
    {
      "affs": [
        0
      ],
      "name": "Hunter Mills"
    },
    {
      "affs": [
        0
      ],
      "name": "Boris Oskotsky"
    },
    {
      "affs": [
        3
      ],
      "name": "Evan Phelps"
    },
    {
      "affs": [
        0
      ],
      "name": "Tomiko T. Oskotsky"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "John A. Capra"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "M. Maria Glymour"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Marina Sirota"
    },
    {
      "affs": [
        5
      ],
      "name": "Elena Tsoy"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9fqvxn4hsqard.bib",
  "cited_by": 0,
  "doi": "10.1002/dad2.70523",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13724300/",
  "id": "9fqvxn4hsqard",
  "issns": [
    "2352-8729"
  ],
  "landing_url": "https://doi.org/10.1002/dad2.70523",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W4412963012",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dad2.70523",
  "pmcid": "PMC13724300",
  "pmid": "42973575",
  "published": "2026-10-01",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/9fqvxn4hsqard.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:22:53Z",
      "native_id": "PMC13724300",
      "source": "pmc",
      "url": "https://doi.org/10.1002/dad2.70523"
    },
    {
      "first_seen": "2026-11-04T15:20:49Z",
      "native_id": "MED:42973575",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42973575"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
    }
  ],
  "title": "Diagnostic reversion in dementia care: A real‐world analysis of mild cognitive impairment diagnoses after dementia in a large electronic medical record system",
  "title_text": "Diagnostic reversion in dementia care: A real‐world analysis of mild cognitive impairment diagnoses after dementia in a large electronic medical record system",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:20:50Z",
  "url": "https://research.draconitic.com/paper/9fqvxn4hsqard",
  "venue": "Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring",
  "versions": []
}