{
  "abstract": "High-resolution extracellular electrophysiology is the gold standard for recording spikes from distributed neural populations and is especially powerful when combined with optogenetics for manipulation of specific cell types with high temporal resolution. We integrated these approaches into prototype Neuropixels Opto probes, which combine electronic and photonic circuits. These devices pack 960 electrical recording sites and two sets of 14 light emitters onto a 70-μm-wide, 1-cm-long shank, allowing spatially addressable optogenetic stimulation with blue and red light. In mouse cortex, Neuropixels Opto probes delivered high-quality recordings together with spatially addressable optogenetics, differentially activating or silencing neurons at distinct cortical depths. In the mouse striatum and other deep structures, Neuropixels Opto probes delivered efficient optotagging, facilitating the identification of two cell types in parallel. Neuropixels Opto probes represent a promising tool for recording, identifying and manipulating neuronal populations.",
  "abstract_shown": true,
  "affiliations": [
    "Allen Institute for Neural Dynamics, Seattle, WA, USA",
    "UCL Institute of Ophthalmology, University College London, London, UK",
    "University College London, London, UK",
    "Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, USA",
    "University of Washington, Seattle, WA, USA",
    "Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA",
    "Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA",
    "IMEC, Leuven, Belgium",
    "Allen Institute for Brain Science, Seattle, WA, USA",
    "Allen Institute MindScope Program, Seattle, WA, USA",
    "Wolfson Institute for Biomedical Research, University College London, London, UK",
    "Allen Institute for Neural Dynamics, Seattle, WA, USA. joshs@alleninstitute.org",
    "UCL Institute of Ophthalmology, University College London, London, UK. m.carandini@ucl.ac.uk"
  ],
  "article_type": null,
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  "author_total": 29,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Anna A. Lakunina",
      "orcid": "0000-0003-2628-8834"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Karolina Z. Socha",
      "orcid": "0000-0002-1677-1489"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Alexander Ladd",
      "orcid": "0000-0003-0999-1608"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Anna J. Bowen",
      "orcid": "0000-0002-8911-2572"
    },
    {
      "affs": [
        5
      ],
      "name": "Susu Chen",
      "orcid": "0000-0002-5065-1157"
    },
    {
      "affs": [
        5
      ],
      "name": "Jennifer I. Colonell",
      "orcid": "0009-0009-3940-0689"
    },
    {
      "affs": [
        0
      ],
      "name": "Anjal Doshi",
      "orcid": "0009-0005-7093-1462"
    },
    {
      "affs": [
        6,
        5
      ],
      "name": "Bill Karsh",
      "orcid": "0009-0009-5977-7731"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Michael Krumin",
      "orcid": "0000-0001-7356-6994"
    },
    {
      "affs": [
        0
      ],
      "name": "Pavel Kulik",
      "orcid": "0009-0005-2222-0324"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Anna J. Li",
      "orcid": "0000-0001-6287-2910"
    },
    {
      "affs": [
        7
      ],
      "name": "Pieter Neutens",
      "orcid": "0000-0002-0620-0033"
    },
    {
      "affs": [
        7
      ],
      "name": "John M. O'Callaghan",
      "orcid": "0000-0003-2313-8697"
    },
    {
      "affs": [
        0
      ],
      "name": "Meghan Olsen",
      "orcid": "0009-0008-1050-935X"
    },
    {
      "affs": [
        7
      ],
      "name": "Jan Putzeys",
      "orcid": "0000-0001-8834-5852"
    },
    {
      "affs": [
        1,
        7
      ],
      "name": "Charu Bai Reddy",
      "orcid": "0000-0002-8195-3326"
    },
    {
      "affs": [
        7,
        4
      ],
      "name": "Harrie A. C. Tilmans",
      "orcid": "0000-0003-4240-4962"
    },
    {
      "affs": [
        8,
        7
      ],
      "name": "Sara Vargas",
      "orcid": "0009-0001-6791-6852"
    },
    {
      "affs": [
        7,
        2
      ],
      "name": "Marleen Welkenhuysen",
      "orcid": "0000-0001-6729-9391"
    },
    {
      "affs": [
        3,
        9
      ],
      "name": "Zhiwen Ye",
      "orcid": "0000-0003-4311-1037"
    },
    {
      "affs": [
        10,
        8
      ],
      "name": "Michael Häusser",
      "orcid": "0000-0002-2673-8957"
    },
    {
      "affs": [
        9,
        7
      ],
      "name": "Christof Koch A",
      "orcid": "0000-0001-6482-8067"
    },
    {
      "affs": [
        8,
        3,
        5
      ],
      "name": "Jonathan T. Ting",
      "orcid": "0000-0001-8266-0392"
    },
    {
      "affs": [
        7,
        4
      ],
      "name": "Barundeb Dutta",
      "orcid": "0000-0003-4781-9630"
    },
    {
      "affs": [
        6,
        5,
        0
      ],
      "name": "T.D. Harris",
      "orcid": "0000-0002-6289-4439"
    },
    {
      "affs": [
        3,
        0
      ],
      "name": "Nicholas A. Steinmetz",
      "orcid": "0000-0001-7029-2908"
    },
    {
      "affs": [
        0,
        5,
        2
      ],
      "name": "Karel Svoboda",
      "orcid": "0000-0002-6670-7362"
    },
    {
      "affs": [
        11
      ],
      "name": "Joshua H. Siegle",
      "orcid": "0000-0002-7736-4844"
    },
    {
      "affs": [
        12
      ],
      "name": "Matteo Carandini",
      "orcid": "0000-0003-4880-7682"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9fsk5pj5zmfxa.bib",
  "cited_by": 22,
  "doi": "10.1038/s41592-026-03076-z",
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  "id": "9fsk5pj5zmfxa",
  "issns": [
    "1548-7091",
    "1548-7105"
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  "landing_url": "https://doi.org/10.1038/s41592-026-03076-z",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
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  "pdf_url": null,
  "pmcid": "PMC11838571",
  "pmid": "39975326",
  "published": "2026-06-01",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/9fsk5pj5zmfxa.ris",
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  "subjects": [
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      "field": "biology",
      "origin": "openalex:2804|Neuroscience and Neural Engineering",
      "subfield": "neuroscience"
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  "title": "Neuropixels Opto: combining high-resolution electrophysiology and optogenetics",
  "title_text": "Neuropixels Opto: combining high-resolution electrophysiology and optogenetics",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:12Z",
  "url": "https://research.draconitic.com/paper/9fsk5pj5zmfxa",
  "venue": "Nature Methods",
  "versions": []
}