{
  "abstract": "In May of 2022, an aquarium-maintained broadnose sevengill shark (Notorynchus cepedianus) developed proliferative skin lesions that prompted pathologic and molecular investigation. Histopathologic examination revealed epidermal hyperplasia consisting of proliferation of spinous epithelial cells with mild dysplasia. Metagenomic sequencing identified a novel adomavirus with an 18,834 base pair circular double-stranded DNA genome. The virus, provisionally named broadnose sevengill shark adomavirus (7AdoV), contains two bidirectionally expressed protein-coding gene sets. Genomic annotation and structural predictions of proteins were used to contextualize 7AdoV phylogenetically and functionally. Transcriptomic analysis showed that expression of the structural late gene set was higher than the replicative early gene set at the time of diagnostic sampling. In situ hybridization using RNAscope technology localized transcripts of the adomavirus Wasp gene to epithelial cells of the hyperplastic epidermis. Infection by this novel adomavirus was associated with superficial and proliferative lesions that were self-limiting and resolved in this shark.",
  "abstract_shown": true,
  "affiliations": [
    "Hubbard Center for Genome Studies, Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH USA",
    "Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD USA",
    "Monterey Bay Aquarium, Monterey, CA USA",
    "New Hampshire Veterinary Diagnostic Laboratory, University of New Hampshire, Durham, NH USA",
    "ZooQuatic Laboratory, LLC, Baltimore, MD USA",
    "Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH USA",
    "Geisel School of Medicine at Dartmouth, Hanover, NH USA",
    "Department of Pathology, University of Texas Medical Branch, Galveston, TX USA",
    "Washington Animal Disease Diagnostic Laboratory, Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA USA",
    "Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Lawrence M. Gordon",
      "orcid": "0009-0007-9201-0554"
    },
    {
      "affs": [
        0
      ],
      "name": "Joseph L. Sevigny"
    },
    {
      "affs": [
        1
      ],
      "name": "Christopher B. Buck"
    },
    {
      "affs": [
        2
      ],
      "name": "Michael J. Murray"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Inga F. Sidor"
    },
    {
      "affs": [
        4
      ],
      "name": "Alisa L. Newton"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Scott M. Palisoul"
    },
    {
      "affs": [
        0
      ],
      "name": "Muriel Kelly"
    },
    {
      "affs": [
        0
      ],
      "name": "Adane S. Nigatu"
    },
    {
      "affs": [
        0
      ],
      "name": "Stephen D. Simpson"
    },
    {
      "affs": [
        7
      ],
      "name": "Vsevolod L. Popov"
    },
    {
      "affs": [
        8
      ],
      "name": "Thomas B. Waltzek"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Gregory J. Tsongalis"
    },
    {
      "affs": [
        4,
        9
      ],
      "name": "Salvatore Frasca"
    },
    {
      "affs": [
        0
      ],
      "name": "W. Kelley Thomas"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9fy1kvbgsqfw2.bib",
  "cited_by": 0,
  "doi": "10.1038/s44298-026-00210-8",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696692/",
  "id": "9fy1kvbgsqfw2",
  "issns": [
    "2948-1767"
  ],
  "landing_url": "https://doi.org/10.1038/s44298-026-00210-8",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "lcc",
      "QH301-705.5"
    ],
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      "lcc",
      "RC109-216"
    ],
    [
      "openalex",
      "2403|Aquaculture disease management and microbiota"
    ]
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  "pdf_url": "https://www.nature.com/articles/s44298-026-00210-8_reference.pdf",
  "pmcid": "PMC13696692",
  "pmid": "42393176",
  "published": "2026-07-01",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/9fy1kvbgsqfw2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:00Z",
      "native_id": "PMC13696692",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s44298-026-00210-8"
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    {
      "first_seen": "2026-11-01T14:21:16Z",
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  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Aquaculture disease management and microbiota",
      "subfield": "immunology"
    }
  ],
  "title": "A novel adomavirus from proliferative skin lesions of a broadnose sevengill shark (Notorynchus cepedianus)",
  "title_text": "A novel adomavirus from proliferative skin lesions of a broadnose sevengill shark (Notorynchus cepedianus)",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T14:20:43Z",
  "url": "https://research.draconitic.com/paper/9fy1kvbgsqfw2",
  "venue": "npj Viruses",
  "versions": []
}