{
  "abstract": "Tau filament types can differ in inter-protofilament packing while sharing the same protofilament fold. Motivated by our recent findings in vacuolar tauopathy, we analyzed cryo-electron microscopy (cryo-EM) data from brain-derived chronic traumatic encephalopathy (CTE) tau filaments deposited in EMPIAR-10313. We resolved the canonical CTE Type I structure and a previously unreported CTE Type I-like structure with a shifted protofilament interface at 2.78 and 2.96 A, respectively. Mapping particle-state assignments back onto the original micrographs showed that the CTE Type I and CTE Type I-like packing states can occupy locally contiguous regions within the same fibrils. These findings identify an interface-shifted CTE Type I-like structure and support its local coexistence with CTE Type I within individual fibrils.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Psychiatry, University of Tsukuba Hospital"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "R. Watanabe"
    },
    {
      "name": "E. B. Lee"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9gcyv5wxahvm4.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.10.750773",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.10.750773v1.full",
  "id": "9gcyv5wxahvm4",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.10.750773v1",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "molecular biology"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.10.750773v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-10",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9gcyv5wxahvm4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:59Z",
      "native_id": "10.64898/2026.09.10.750773",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.10.750773v2"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "biorxiv:molecular biology",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Structural heterogeneity of CTE Type I tau filaments with an interface-shifted polymorph",
  "title_text": "Structural heterogeneity of CTE Type I tau filaments with an interface-shifted polymorph",
  "type": "preprint",
  "updated_at": "2026-10-30T12:22:37Z",
  "url": "https://research.draconitic.com/paper/9gcyv5wxahvm4",
  "venue": "bioRxiv",
  "versions": [
    {
      "doi": "10.1016/j.bbrc.2026.154679",
      "pid": null,
      "relation": "published-as",
      "title": null,
      "venue": null
    }
  ]
}