{
  "abstract": "Transient K+ efflux occurs rapidly following pathogen-associated molecular pattern (PAMP) perception by pattern recognition receptors (PRRs) as part of pattern-triggered immunity (PTI). However, the molecular identities of the K+ channels responsible for PTI-associated K+ efflux and the mechanisms linking immune signaling to K+ channel regulation remain largely unknown. Here, we show that the channel GUARD CELL OUTWARD RECTIFYING K+ (GORK) is required for K+ efflux and stomatal closure induced by flg22, a model PAMP derived from bacterial flagellin. BOTRYTIS-INDUCED KINASE 1 (BIK1), a receptor-like cytoplasmic kinase associated with immune receptor complexes that functions as a central regulator of PTI, interacts with GORK and phosphorylates the channel on the conserved T199 residue in vitro. Electrophysiological analyses indicate that BIK1 inhibits GORK activity in a kinase-dependent manner and that T199 plays an essential role for GORK function. Together, this study identifies GORK as the key K+ channel executing rapid PTI-associated K+ efflux and associated stomatal closure, thus shedding light on the mechanisms of early immune signaling.",
  "abstract_shown": true,
  "affiliations": [
    "The Sainsbury Laboratory"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "name": "L. Wang"
    },
    {
      "name": "L. Yue"
    },
    {
      "name": "R. Toth"
    },
    {
      "name": "S. Choi"
    },
    {
      "name": "S. Zhang"
    },
    {
      "name": "T. Maierhofer"
    },
    {
      "name": "S. Snoeck"
    },
    {
      "name": "G. Kim"
    },
    {
      "name": "K. W. Bender"
    },
    {
      "name": "Y. Lee"
    },
    {
      "name": "D. Geiger"
    },
    {
      "name": "T. A. DeFalco"
    },
    {
      "name": "R. Hedrich"
    },
    {
      "affs": [
        0
      ],
      "name": "C. Zipfel"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9gd7fcgq2b08h.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.10.758189",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.10.758189v1.full",
  "id": "9gd7fcgq2b08h",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.10.758189v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "plant biology"
    ],
    [
      "openalex",
      "1110|Plant-Microbe Interactions and Immunity"
    ]
  ],
  "openalex": "W7221592434",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.10.758189v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-10",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9gd7fcgq2b08h.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:27:32Z",
      "native_id": "10.64898/2026.10.10.758189",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.10.758189v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:plant biology",
      "subfield": "plant-biology"
    }
  ],
  "title": "The Arabidopsis outward K+ channel GORK mediates flg22-induced K+ efflux and stomatal closure",
  "title_text": "The Arabidopsis outward K+ channel GORK mediates flg22-induced K+ efflux and stomatal closure",
  "type": "preprint",
  "updated_at": "2026-10-30T12:27:32Z",
  "url": "https://research.draconitic.com/paper/9gd7fcgq2b08h",
  "venue": "bioRxiv",
  "versions": []
}