{
  "abstract": "Objectives: Cardiovascular disease is the leading cause of death in rheumatoid arthritis (RA). By replacing C-reactive protein (CRP) with gamma-glutamyl transferase (GGT), the DAS28-GGT was developed to integrate both inflammatory disease activity and cardiovascular (CV) risk into a single score. We evaluated its ability to classify CV risk in RA patients initiating Janus kinase inhibitors (JAKi) and compared its performance with DAS28-CRP. Methods: This cross-sectional study used data from the MAJIK-SFR observational registry. RA patients initiating a JAKi with available GGT were included. CV risk was estimated using the SCORE2 and Framingham equations. The discriminative performance of the DAS28-GGT was assessed using ROC curves and compared with the DeLong test. DAS28-GGT discrimination across DAS28-CRP disease activity categories was assessed. Results: We included 185 RA patients (72% women, mean age 58±13years). Mean DAS28-CRP was 4.07±1.27 and mean DAS28-GGT 8.88±1.83. According to SCORE2, 54.3% patients were at low, 38.9% at moderate, and 6.8% at high CV risk and 34.8%, 44.7%, and 20.5%, according to Framingham, respectively. DAS28-GGT better discriminated patients with at least moderate CV risk than DAS28-CRP (SCORE2 AUC 0.59 vs 0.52, P<0.05; Framingham AUC 0.63 vs 0.53, P<0.01). DAS28-GGT significantly discriminated DAS28-CRP remission, low, and high disease activity (AUCs 0.91, 0.70, and 0.83 respectively). Conclusion: This study supports the DAS28-GGT as a simple and practical tool to capture both cardiovascular risk and inflammatory activity in RA patients initiating JAKi. Prospective studies are needed to confirm its value for predicting cardiovascular events.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 19,
  "authors": [
    {
      "name": "Léa Perrot"
    },
    {
      "name": "Jerôme Avouac"
    },
    {
      "name": "Marie-Elise Truchetet"
    },
    {
      "name": "Clément Prati"
    },
    {
      "name": "Jean Hugues Salmon"
    },
    {
      "name": "René Marc Flipo"
    },
    {
      "name": "Christian Roux"
    },
    {
      "name": "André Basch"
    },
    {
      "name": "Emmanuelle Dernis"
    },
    {
      "name": "Carine Salliot"
    },
    {
      "name": "Fabienne Coury"
    },
    {
      "name": "Claire Immediato Daien"
    },
    {
      "name": "Philipe Goupille"
    },
    {
      "name": "Thierry Thomas"
    },
    {
      "name": "Béatrice Banneville"
    },
    {
      "name": "Claire Martin"
    },
    {
      "name": "Adeline Ruyssen-Witrand"
    },
    {
      "name": "Roch Giorgi"
    },
    {
      "name": "Thao Pham"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9gfcay131m3tf.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jbspin.2026.106113",
  "fulltext_url": null,
  "id": "9gfcay131m3tf",
  "issns": [
    "1297-319X"
  ],
  "landing_url": "https://inserm.hal.science/inserm-05848819v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.spee"
    ],
    [
      "openalex",
      "2745|Rheumatoid Arthritis Research and Therapies"
    ]
  ],
  "openalex": "W7169793626",
  "pdf_url": "https://inserm.hal.science/inserm-05848819/document",
  "pmcid": null,
  "pmid": "42476357",
  "published": "2026-11-02",
  "publisher": "Elsevier Masson",
  "ris": "https://research.draconitic.com/paper/9gfcay131m3tf.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:20:17Z",
      "native_id": "inserm-05848819",
      "source": "hal",
      "url": "https://inserm.hal.science/inserm-05848819v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.spee",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Cardiovascular risk assessment using the DAS28-GGT score in rheumatoid arthritis patients initiating JAK inhibitors: Results from the MAJIK-SFR registry",
  "title_text": "Cardiovascular risk assessment using the DAS28-GGT score in rheumatoid arthritis patients initiating JAK inhibitors: Results from the MAJIK-SFR registry",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:20:48Z",
  "url": "https://research.draconitic.com/paper/9gfcay131m3tf",
  "venue": "Joint Bone Spine",
  "versions": []
}