{
  "abstract": "The Hippo pathway and its downstream effectors, YAP/TAZ, exhibit aberrant regulation in head and neck squamous cell carcinoma, facilitating cancer cell growth. However, the influence of YAP/TAZ on cancer immune evasion remains poorly understood. Herein, we show that cancer patients harboring mutations regulating the Hippo pathway and YAP/TAZ hyperactivation may be sensitized to immune checkpoint inhibitor (ICI) therapy owing to genome instability and PD-L2 expression. LATS1/2 deletion, accompanied by YAP/TAZ hyperactivation, was associated with loss of squamous differentiation and genome instability, which may contribute to elevated DNA damage. Our data suggest that YAP/TAZ may recruit TEAD, BRD4, and RNA polymerase Ⅱ to the super-enhancer and promoter regions of PD-L1 and PD-L2 . YAP/TAZ predominantly contribute to PD-L2 expression, which is associated with Stat3 activation, partially enhancing PD-L1 transcription. YAP/TAZ-activated cells can be targeted by antigen-specific T cells but evade them through PD-L2. These findings suggest that Hippo pathway alterations and associated YAP/TAZ hyperactivation may serve as potential prognostic factors for stratifying patients undergoing ICI therapy. Targeting YAP/TAZ/TEAD could offer a promising treatment avenue for cancers harboring YAP/TAZ hyperactivation.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
      "name": "Toshinori Ando",
      "orcid": "0000-0002-3141-8173"
    },
    {
      "name": "Kento Okamoto"
    },
    {
      "name": "Kuniaki Sato",
      "orcid": "0000-0001-6014-1911"
    },
    {
      "name": "Yusuke Goto",
      "orcid": "0000-0001-7720-9740"
    },
    {
      "name": "Hiroki Izumi"
    },
    {
      "name": "Nanako Kataoka"
    },
    {
      "name": "Yume Ueda"
    },
    {
      "name": "Yukina Kobayashi"
    },
    {
      "name": "Kai Omachi"
    },
    {
      "name": "Yuga Maeda"
    },
    {
      "name": "Hisako Furusho"
    },
    {
      "name": "Ramiro Iglesias-Bartolome"
    },
    {
      "name": "Tetsuya Yoshimoto"
    },
    {
      "name": "Tomoaki Shintani",
      "orcid": "0000-0002-0789-3273"
    },
    {
      "name": "Souichi Yanamoto"
    },
    {
      "name": "Mutsumi Miyauchi"
    },
    {
      "name": "J. Silvio Gutkind"
    },
    {
      "name": "Mikihito Kajiya",
      "orcid": "0000-0001-6652-0007"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9h6k5tk2wr0fa.bib",
  "cited_by": 0,
  "doi": "10.1038/s42003-026-11092-0",
  "fulltext_url": "https://europepmc.org/articles/PMC13694708",
  "id": "9h6k5tk2wr0fa",
  "issns": [
    "2399-3642"
  ],
  "landing_url": "https://www.nature.com/articles/s42003-026-11092-0",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QH301-705.5"
    ],
    [
      "openalex",
      "1307|Hippo pathway signaling and YAP/TAZ"
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  "openalex": "W7223415321",
  "pdf_url": "https://www.nature.com/articles/s42003-026-11092-0.pdf",
  "pmcid": "PMC13694708",
  "pmid": "42919899",
  "published": "2026-10-23",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/9h6k5tk2wr0fa.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:50Z",
      "native_id": "10.1038/s42003-026-11092-0",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s42003-026-11092-0"
    },
    {
      "first_seen": "2026-10-30T12:20:33Z",
      "native_id": "MED:42919899",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42919899"
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    {
      "first_seen": "2026-10-30T13:46:26Z",
      "native_id": "d124b9b6967a49f4a64ef9f084e8d5a2",
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      "url": "https://doi.org/10.1038/s42003-026-11092-0"
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  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1307|Hippo pathway signaling and YAP/TAZ",
      "subfield": "cell-biology"
    }
  ],
  "title": "Dysregulation of the Hippo pathway enhances PD-L2 transcription to promote immune evasion in head and neck squamous cell carcinoma",
  "title_text": "Dysregulation of the Hippo pathway enhances PD-L2 transcription to promote immune evasion in head and neck squamous cell carcinoma",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:26Z",
  "url": "https://research.draconitic.com/paper/9h6k5tk2wr0fa",
  "venue": "Communications Biology",
  "versions": []
}