{
  "abstract": "Background\n\nIntestinal metaplasia (IM) is a key precancerous lesion connecting chronic atrophic gastritis and gastric cancer in the Correa cascade, and its risk of progression has significant individual heterogeneity. A potential explanatory framework for this heterogeneity involves interactions between gastric microbiota imbalance and host epigenetic remodeling. Current research needs to clarify the relationship between microbial community stratification and IM reversibility, particularly whether high-risk microbial signatures and putative epigenetic \"silencer locking\" states are associated with IM regression or persistence.Method\n\nThis hypothesis-driven narrative review synthesizes representative findings from metagenomic, metabolomic, transcriptomic, and epigenomic studies to develop a conceptual framework for how interactions between Helicobacter pylori (H. pylori), non-H. pylori microorganisms, and host mucosal responses may be associated with the initiation and progression of IM, potentially through microbiota-associated, host-derived, and mixed-origin metabolic signals that converge on epigenetic and transcriptional regulation.Result\n\nAvailable evidence suggests that microbial networks in IM may include potential pro-inflammatory interactions between H. pylori and taxa such as Fusobacterium nucleatum (F. nucleatum), as well as possible protective associations involving beneficial bacteria such as Lactobacillus. Based on this, we propose a three-stage working model, H. pylori initiation, putative microbial network amplification, and silencer remodeling-associated progression, and discuss a candidate intervention framework involving probiotics, miR-185, and Wnt/β-catenin signaling, which should be regarded as a testable hypothesis rather than a clinically validated reversal strategy.Conclusion\n\nThese findings may provide candidate mechanistic targets and a theoretical basis for future risk stratification, dynamic monitoring, and individualized intervention of IM, pending validation in prospective clinical studies.",
  "abstract_shown": true,
  "affiliations": [
    "Affiliated Hospital of Jiangnan University, Wuxi City, Jiangsu Province, 214122, China.",
    "Jiangnan University, 1000 Hefeng Road, Binhu District, Wuxi City, Jiangsu Province, 214122, China.",
    "Affiliated Hospital of Jiangnan University, Wuxi City, Jiangsu Province, 214122, China. xueyz001@163.com.",
    "Jiangnan University, 1000 Hefeng Road, Binhu District, Wuxi City, Jiangsu Province, 214122, China. xueyz001@163.com."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yingyue Sheng"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Chaosheng Yan"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yuzhe Yin"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhipeng Zeng"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Xinyu Pei"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Chenyu Ma"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jingjing Rao"
    },
    {
      "affs": [
        0
      ],
      "name": "Haowen Sun"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Yuzheng Xue"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9h7m21g2f0trj.bib",
  "cited_by": 0,
  "doi": "10.1186/s12967-026-08730-w",
  "fulltext_url": "https://europepmc.org/articles/PMC13721604",
  "id": "9h7m21g2f0trj",
  "issns": [
    "1479-5876"
  ],
  "landing_url": "https://europepmc.org/article/MED/42958549",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2746|Helicobacter pylori-related gastroenterology studies"
    ]
  ],
  "openalex": "W7171923726",
  "pdf_url": "https://europepmc.org/articles/PMC13721604?pdf=render",
  "pmcid": "PMC13721604",
  "pmid": "42958549",
  "published": "2026-07-31",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/9h7m21g2f0trj.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:47Z",
      "native_id": "MED:42958549",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42958549"
    },
    {
      "first_seen": "2026-11-03T12:22:16Z",
      "native_id": "PMC13721604",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12967-026-08730-w"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Helicobacter pylori-related gastroenterology studies",
      "subfield": "surgery"
    }
  ],
  "title": "From microbial dysbiosis to putative epigenetic locking: a hypothesis-driven framework for the pathogenesis and future therapeutic perspectives of gastric intestinal metaplasia.",
  "title_text": "From microbial dysbiosis to putative epigenetic locking: a hypothesis-driven framework for the pathogenesis and future therapeutic perspectives of gastric intestinal metaplasia.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:16Z",
  "url": "https://research.draconitic.com/paper/9h7m21g2f0trj",
  "venue": "Journal of translational medicine",
  "versions": []
}