{
  "abstract": "Glioblastoma (GBM) bears sustained intratumoral hypoxia that blocks oxygen-dependent photodynamic therapy (PDT). Hypoxia suppresses Type II photochemical reactions and singlet oxygen (¹O₂) generation, while oxygen-free photothermal therapy (PTT) can complement PDT for synergistic tumor suppression. Copper phthalocyanine DL-86 is a single NIR dual-responsive photosensitizer capable of simultaneous ROS and heat production, yet its anti-tumor potency is limited by tumor hypoxia and poor cellular uptake. Herein, microfluidics was adopted to fabricate self-oxygenated liposomes DL-86@CAT@Lip co-loaded with DL-86 and catalase (CAT). The uniform spherical nanoparticles (114.7 nm) exhibited excellent colloidal and serum stability. Encapsulated CAT decomposed intracellular H₂O₂ to relieve hypoxia, and the nanosystem achieved a photothermal conversion efficiency of 46.15%. Under 660 nm laser irradiation, combined PDT/PTT drastically reduced hypoxic C6 glioma cell viability to ~20.3%. Hemolysis tests confirmed favorable intravenous hemocompatibility. This work first proves that the self-oxygenation liposomal platform enhances hypoxic anti-GBM dual phototherapy, supplying an in vitro concept and a blueprint for brain tumor phototherapeutic nanomedicines.",
  "abstract_shown": true,
  "affiliations": [
    "Central Laboratory of YunFu People’s Hospital, YunFu Key Laboratory of Brain Diseases Research, YunFu People’s Hospital, Guangdong 527300 Yunfu, China",
    "Guangzhou University of Chinese Medicine, 510006 Guangzhou, China",
    "Department of Biology, Faculty of Arts and Sciences, Beijing Normal University, 519087 Zhuhai, China",
    "School of Pharmacy, Mudanjiang Medical University, 157011 Mudanjiang, China",
    "Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Victoria Parkville, Australia"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jun Gong"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Xiaoming Pan"
    },
    {
      "affs": [
        2
      ],
      "name": "Shichao Wang"
    },
    {
      "affs": [
        3
      ],
      "name": "Yifan Liu"
    },
    {
      "affs": [
        3
      ],
      "name": "Guangwei Wang"
    },
    {
      "affs": [
        3
      ],
      "name": "Min Yu"
    },
    {
      "affs": [
        4
      ],
      "name": "Pu Chun Ke"
    },
    {
      "affs": [
        2
      ],
      "name": "Mengze Xu",
      "orcid": "0000-0002-2614-733X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9hc1kv9501qw5.bib",
  "cited_by": 0,
  "doi": "10.1186/s11671-026-05081-9",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13713955/",
  "id": "9hc1kv9501qw5",
  "issns": [
    "2731-9229"
  ],
  "landing_url": "https://doi.org/10.1186/s11671-026-05081-9",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2204|Nanoplatforms for cancer theranostics"
    ]
  ],
  "openalex": "W7224023557",
  "pdf_url": null,
  "pmcid": "PMC13713955",
  "pmid": "42944975",
  "published": "2026-10-27",
  "publisher": "Springer",
  "ris": "https://research.draconitic.com/paper/9hc1kv9501qw5.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:21:32Z",
      "native_id": "PMC13713955",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s11671-026-05081-9"
    }
  ],
  "subjects": [],
  "title": "Microfluidically fabricated self-oxygen-supplied DL-86 lipid nanoplatform for in vitro synergistic photodynamic/photothermal dual phototherapy against hypoxia-tolerant glioblastoma",
  "title_text": "Microfluidically fabricated self-oxygen-supplied DL-86 lipid nanoplatform for in vitro synergistic photodynamic/photothermal dual phototherapy against hypoxia-tolerant glioblastoma",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:32Z",
  "url": "https://research.draconitic.com/paper/9hc1kv9501qw5",
  "venue": "Discover Nano",
  "versions": []
}