{
  "abstract": "Blood pressure variability (BPV) is an established predictor of cardiovascular risk, yet its physiologic determinants in specific populations remain incompletely defined. Neurodegenerative diseases are associated with autonomic dysfunction that may alter blood pressure regulation. We compared day-to-day systolic blood pressure (SBP) variability between patients with neurodegenerative disease and matched controls in a retrospective analysis of de-identified home blood pressure data from a remote patient monitoring platform. Eligible patients transmitted readings on at least three days per week over a monitoring stretch of at least eight weeks. Patients with Alzheimer's disease, Parkinson's disease, or dementia were propensity-matched 1:3 to controls on age, mean SBP, mean diastolic blood pressure (DBP), stretch duration, and days per week with readings. The primary metric was average real variability (ARV), the mean absolute difference between consecutive values; standard deviation (SD) and variability independent of the mean (VIM) were secondary metrics. The matched cohort included 49 neurodegenerative patients and 147 controls. SBP ARV was higher in the neurodegenerative group (median 12.92 [IQR 10.74-15.35] vs. 11.19 [9.46-12.99] mmHg; p = 0.003), as was DBP ARV (7.72 [6.34-8.87] vs. 6.76 [5.67-7.75] mmHg; p = 0.002). SD and VIM results were concordant (all p ≤ 0.001). Mean blood pressure, monitoring duration, measurement frequency, and reading timing were comparable between groups. Neurodegenerative disease is associated with elevated day-to-day BPV despite similar mean blood pressure and monitoring behavior, suggesting that routine home monitoring may reveal autonomic dysregulation and cardiovascular risk beyond mean blood pressure alone.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Kinesiology and Sport Sciences, University of Miami, Miami, Florida, USA.",
    "HealthSnap, Inc., Miami, Florida, USA.",
    "Department of Informatics and Health Data Science, University of Miami, Miami, Florida, USA.",
    "Department of Psychiatry and Behavioral Sciences, University of Miami, Miami, Florida, USA.",
    "Tulane University, New Orleans, Louisiana, USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Wesley Smith"
    },
    {
      "affs": [
        0
      ],
      "name": "Joseph F Signorile"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Azizi A Seixas"
    },
    {
      "affs": [
        3
      ],
      "name": "Debbie P Chung"
    },
    {
      "affs": [
        3
      ],
      "name": "Brittany Larsen"
    },
    {
      "affs": [
        1,
        4
      ],
      "name": "Craig Flanagan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9hpz819x6jhjd.bib",
  "cited_by": 0,
  "doi": "10.1111/jch.70379",
  "fulltext_url": "https://europepmc.org/articles/PMC13744429",
  "id": "9hpz819x6jhjd",
  "issns": [
    "1524-6175",
    "1751-7176"
  ],
  "landing_url": "https://europepmc.org/article/MED/42998901",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2705|Blood Pressure and Hypertension Studies"
    ]
  ],
  "openalex": "W7225463235",
  "pdf_url": "https://europepmc.org/articles/PMC13744429?pdf=render",
  "pmcid": "PMC13744429",
  "pmid": "42998901",
  "published": "2026-11-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9hpz819x6jhjd.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:34Z",
      "native_id": "MED:42998901",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42998901"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Blood Pressure and Hypertension Studies",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Blood Pressure Variability in Neurodegenerative Disease: Evidence From a Large-Scale Remote Patient Monitoring Program.",
  "title_text": "Blood Pressure Variability in Neurodegenerative Disease: Evidence From a Large-Scale Remote Patient Monitoring Program.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:34Z",
  "url": "https://research.draconitic.com/paper/9hpz819x6jhjd",
  "venue": "Journal of clinical hypertension (Greenwich, Conn.)",
  "versions": []
}