{
  "abstract": "PTEN loss activates PI3K–AKT signaling, and mTORC1 stimulates pyrimidine synthesis through S6K1-mediated CAD phosphorylation. This exploratory public-data analysis tested whether PTEN deletion in primary prostate cancer is associated with CAD, mTORC1 and pyrimidine-synthesis expression, and whether these survive protein-level and confounder analyses. In 485 primary tumors from The Cancer Genome Atlas Prostate Adenocarcinoma (TCGA-PRAD; 159 PTEN-deleted), deletion was associated with higher CAD mRNA (Hedges’ g = 0.57) and higher Hallmark mTORC1 scores (g = 0.54). In 342 tumors with reverse-phase protein-array data, deletion was accompanied by lower PTEN protein and higher AKT Ser473 phosphorylation but not by a higher pre-specified mTORC1 phospho-output composite (g = −0.02), itself uncorrelated with the transcriptional score. In a pre-specified model adding purity, TP53, RB1, ERG fusion and batch (n = 276), the PTEN–CAD association was absent (β = −0.002; p = 0.96), whereas the mTORC1-score association persisted. In a post hoc decomposition, ERG fusion, which co-occurs with PTEN deletion (odds ratio 3.6), changed the coefficient most. Across eight cohorts, a small PTEN mRNA–CAD association (g = 0.23) was attenuated to 0.14 after ERG adjustment, with overlapping confidence intervals (Hartung–Knapp p = 0.071). Bulk-tumor pathway signatures and PTEN–CAD associations need protein-level and ERG-aware interpretation.",
  "abstract_shown": true,
  "affiliations": [
    "College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia",
    "Department of Biotechnology, Utkal University, Vani Vihar, Bhubaneswar 751004, Odisha, India",
    "Department of Health Informatics, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi Arabia",
    "College of Science and Health Professions, King Saud Bin Abdulaziz University for Health Sciences, Riyadh 11481, Saudi Arabia",
    "King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard–Health Affairs, Riyadh 11481, Saudi Arabia",
    "Department of Biotechnology, School of Life Sciences, Central University of Kashmir, Ganderbal 191201, Jammu and Kashmir, India",
    "Research Center, King Faisal Specialist Hospital and Research Center, Jeddah 21499, Saudi Arabia"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Itika Arora"
    },
    {
      "affs": [
        1
      ],
      "name": "Suvasmita Rath"
    },
    {
      "affs": [
        2
      ],
      "name": "Qazi Mohammad Sajid Jamal",
      "orcid": "0000-0001-5525-708X"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Ahmed Aljohani"
    },
    {
      "affs": [
        5
      ],
      "name": "Abid Hamid"
    },
    {
      "affs": [
        0
      ],
      "name": "Ahmed Abu-Zaid"
    },
    {
      "affs": [
        6
      ],
      "name": "Mohammad Imran Khan"
    },
    {
      "affs": [
        0
      ],
      "name": "Ahmed Yaqinuddin",
      "orcid": "0000-0001-7536-910X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9j7bv7qk269jw.bib",
  "cited_by": 0,
  "doi": "10.3390/cells15211997",
  "fulltext_url": null,
  "id": "9j7bv7qk269jw",
  "issns": [
    "2073-4409"
  ],
  "landing_url": "https://www.mdpi.com/2073-4409/15/21/1997",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-31",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/9j7bv7qk269jw.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T00:24:04Z",
      "native_id": "10.3390/cells15211997",
      "source": "crossref",
      "url": "https://www.mdpi.com/2073-4409/15/21/1997"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:2073-4409",
      "subfield": "cell-biology"
    }
  ],
  "title": "PTEN Deletion, mTORC1 Signatures and CAD Expression in Primary Prostate Cancer: Protein-Level Data and the Role of ERG Fusion",
  "title_text": "PTEN Deletion, mTORC1 Signatures and CAD Expression in Primary Prostate Cancer: Protein-Level Data and the Role of ERG Fusion",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T00:24:56Z",
  "url": "https://research.draconitic.com/paper/9j7bv7qk269jw",
  "venue": "Cells",
  "versions": []
}