{
  "abstract": "Blood progenitors are regulated by a variety of systemic and nutritional cues from their environment. In the Drosophila lymph gland (LG), the Posterior Signaling Center acts as a stem cell niche striking a balance between progenitors and differentiated blood cells. Autophagy is a vital cellular process that maintains homeostasis by removing unnecessary or dysfunctional cell components through autophagic degradation and recycling. Here, using genetic perturbation analysis, we show that autophagy plays a critical role in regulating LG blood cell homeostasis. General control non-derepressible 5 (Gcn5), a histone acetyltransferase, is expressed in the primary LG lobe, and modulation of Gcn5 levels perturbs LG homeostasis. Our results show that hemocyte-specific Gcn5 modulation controls autophagic flux in the hemocytes. Furthermore, we show that modulation of mTORC1 activity can perturb hematopoiesis. Our results indicate that organismal Gcn5 levels respond to dietary shifts and are modulated by mTORC1 signaling. Chemical intervention shows that mTORC1 overrides the effect exerted by Gcn5 in regulating LG hematopoiesis. Taken together, our findings demonstrate that Gcn5 and mTORC1 regulate autophagy to maintain blood cell homeostasis in Drosophila.",
  "abstract_shown": true,
  "affiliations": [
    "Stem Cell and Tissue Homeostasis Laboratory, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India",
    "Champalimaud Research, Champalimaud Foundation, Lisboa, Portugal",
    "Homi Bhabha National Institute, Training School Complex, Mumbai, India",
    "Center for Genomic Medicine, Massachusetts General Hospital, Boston, United States"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Arjun Aji Reeja",
      "orcid": "0000-0002-1127-4491"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Mincy Kunjumon",
      "orcid": "0009-0001-5667-0586"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Suraj Math"
    },
    {
      "affs": [
        0
      ],
      "name": "Laxmi Kata"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Rohan Jayant Khadilkar",
      "orcid": "0000-0002-7297-2736"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9jfryws416tg2.bib",
  "cited_by": 1,
  "doi": "10.7554/elife.91615",
  "fulltext_url": "https://elifesciences.org/articles/91615",
  "id": "9jfryws416tg2",
  "issns": [
    "2050-084X"
  ],
  "landing_url": "https://elifesciences.org/articles/91615",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "elife",
      "developmental-biology"
    ],
    [
      "openalex",
      "2403|Invertebrate Immune Response Mechanisms"
    ]
  ],
  "openalex": "W4390707207",
  "pdf_url": "https://cdn.elifesciences.org/articles/91615/elife-91615-v1.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-05",
  "publisher": "eLife Sciences Publications",
  "ris": "https://research.draconitic.com/paper/9jfryws416tg2.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T12:20:15Z",
      "native_id": "91615",
      "source": "elife",
      "url": "https://elifesciences.org/articles/91615"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "elife:developmental-biology",
      "subfield": "developmental-biology"
    }
  ],
  "title": "Gcn5 and mTORC1 mediated regulation of autophagy controls Drosophila blood cell homeostasis",
  "title_text": "Gcn5 and mTORC1 mediated regulation of autophagy controls Drosophila blood cell homeostasis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:20:47Z",
  "url": "https://research.draconitic.com/paper/9jfryws416tg2",
  "venue": "eLife",
  "versions": []
}