{
  "abstract": "INTRODUCTIONDetermining whether plasma biomarkers are preferentially associated with Alzheimers disease (AD)-related rather than age-related brain atrophy patterns may clarify their prognostic and diagnostic clinical use.\n\nMETHODSUsing data from the Baltimore Longitudinal Study of Aging (N=818), we examined cross-sectional plasma A{beta}42/A{beta}40, GFAP, NfL, p-tau181, and p-tau217 measurements obtained while participants were cognitively unimpaired (CU). During follow-up, 104 participants developed mild cognitive impairment (MCI)/dementia (74 due to AD, 24 due to non-AD, 6 unknown etiology). 2,293 longitudinal brain MRIs were used to quantify multidimensional atrophy pattern scores reflecting brain age (SPARE-BA), AD-like patterns (SPARE-AD), and five dominant dimensions of atrophy (R-indices). We investigated the associations of plasma biomarkers and atrophy pattern scores at index visit with conversion to MCI/dementia due to AD. We then examined the associations of plasma biomarkers with longitudinal change in pattern scores using linear mixed effects models.\n\nRESULTSp-tau181, A{beta}42/A{beta}40 (Lumipulse), and p-tau217 were associated with incident MCI/dementia due to AD but not non-AD etiologies, while GFAP was associated with incident MCI/dementia due to both AD and non-AD. All four biomarkers were associated with longitudinal SPARE-AD changes. A{beta}42/A{beta}40 (Quanterix and Lumipulse), p-tau181, and p-tau217 were associated with longitudinal parieto-temporal atrophy. p-tau217 was the only biomarker associated with longitudinal medial temporal lobe atrophy. We did not find associations between plasma biomarkers and SPARE-BA or R-indices capturing subcortical, diffuse cortical, or perisylvian atrophy.\n\nDISCUSSIONAmong CU individuals, plasma p-tau217 was associated with subsequent MCI/dementia due to AD and showed the most extensive associations with longitudinal AD-related brain atrophy.",
  "abstract_shown": true,
  "affiliations": [
    "National Institute on Aging"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "M. Bilgel"
    },
    {
      "name": "I. Shah"
    },
    {
      "name": "J. Cooper"
    },
    {
      "name": "Y. An"
    },
    {
      "name": "K. A. Walker"
    },
    {
      "name": "S. G. Ho"
    },
    {
      "name": "A. R. Moghekar"
    },
    {
      "name": "Z. Yang"
    },
    {
      "name": "G. Erus"
    },
    {
      "name": "C. Davatzikos"
    },
    {
      "name": "L. Ferrucci"
    },
    {
      "name": "S. M. Resnick"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9jy4vx97y00xz.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.11.26362869",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.09.11.26362869v1.full",
  "id": "9jy4vx97y00xz",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.09.11.26362869v1",
  "language": null,
  "licence": "CC0-1.0",
  "licence_label": "CC0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/publicdomain/zero/1.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "radiology and imaging"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.09.11.26362869v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-11",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9jy4vx97y00xz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:47Z",
      "native_id": "10.64898/2026.09.11.26362869",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.09.11.26362869v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:radiology and imaging",
      "subfield": "imaging"
    }
  ],
  "title": "Association of plasma biomarkers with longitudinal change in age- and Alzheimer's disease-related brain atrophy patterns",
  "title_text": "Association of plasma biomarkers with longitudinal change in age- and Alzheimer's disease-related brain atrophy patterns",
  "type": "preprint",
  "updated_at": "2026-10-30T12:18:47Z",
  "url": "https://research.draconitic.com/paper/9jy4vx97y00xz",
  "venue": "medRxiv",
  "versions": []
}