{
  "abstract": "The global incidence of colorectal cancer (CRC) is rising at an alarming rate, particularly among individuals under the age of 50, referred to as early-onset CRC (EOCRC). While genetic predisposition accounts for approximately 20% of the total cases, the majority are influenced by environmental and lifestyle factors. Among these, the rising prevalence of obesity is a major modifiable contributor to EOCRC pathogenesis.This narrative review explores the multifaceted role of obesity in EOCRC, focusing on how diet-induced adiposity reshapes the gut microbiota and host metabolic signaling.We synthesize evidence on how obesity-associated dysbiosis, characterized by the depletion of protective, short-chain fatty acid (SCFA)-producing bacteria and the enrichment of genotoxic pathobionts, compromises intestinal barrier integrity and promotes a “leaky gut” phenotype. In addition, we explore the systemic consequences of obesity-driven inflammation, including M1-polarized macrophage infiltration into adipose tissue, dysregulated adipokine signaling, and the hyperactivation of the insulin-IGF-1 axis.By integrating epidemiological data with molecular mechanisms, this review highlights how the synergy between metabolic dysfunction and microbial alterations creates a fertile niche for early-onset carcinogenesis. These findings underscore the importance of targeting lifestyle interventions to mitigate the rising burden of obesity and reduce the risk of EOCRC progression.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia",
    "Department of Basic Medical Sciences, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Sarawak, Malaysia"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "SITI MARYAM AHMAD KENDONG"
    },
    {
      "affs": [
        0
      ],
      "name": "NURUL NADIRAH RAZALI"
    },
    {
      "affs": [
        1
      ],
      "name": "MYAT SU BO"
    },
    {
      "affs": [
        1
      ],
      "name": "MARLYNNA SARKAWI"
    },
    {
      "affs": [
        0
      ],
      "name": "MOHD HELMY MOKHTAR"
    },
    {
      "affs": [
        0
      ],
      "name": "ADILA A. HAMID"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9k2yd9fk4mpzv.bib",
  "cited_by": 0,
  "doi": "10.21873/invivo.14478",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13723955/",
  "id": "9k2yd9fk4mpzv",
  "issns": [
    "0258-851X",
    "1791-7549"
  ],
  "landing_url": "https://doi.org/10.21873/invivo.14478",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review Article"
    ],
    [
      "openalex",
      "1312|Gut microbiota and health"
    ]
  ],
  "openalex": "W7224526136",
  "pdf_url": "https://iv.iiarjournals.org/content/invivo/40/6/3297.full.pdf",
  "pmcid": "PMC13723955",
  "pmid": "42957227",
  "published": "2026-10-29",
  "publisher": "International Institute of Anticancer Research",
  "ris": "https://research.draconitic.com/paper/9k2yd9fk4mpzv.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:22:30Z",
      "native_id": "PMC13723955",
      "source": "pmc",
      "url": "https://doi.org/10.21873/invivo.14478"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Gut microbiota and health",
      "subfield": "molecular-biology"
    }
  ],
  "title": "The Interplay Between Obesity, Gut Microbiota and Early-onset Colorectal Cancer",
  "title_text": "The Interplay Between Obesity, Gut Microbiota and Early-onset Colorectal Cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:20:41Z",
  "url": "https://research.draconitic.com/paper/9k2yd9fk4mpzv",
  "venue": "In Vivo",
  "versions": []
}