{
  "abstract": "Gastaldo et al. 1 report that lowering ataxin-2 protects neurons from TDP-43 toxicity in amyotrophic lateral sclerosis by activating neuronal glycolysis and astrocytic cholesterol synthesis, not by reversing TDP-43-dependent molecular pathology. The downstream effectors, IDH1 and HMGCS1, thus emerge as candidate therapeutic targets.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
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  "author_total": 2,
  "authors": [
    {
      "name": "Fabiana Longo",
      "orcid": "0000-0002-1040-0476"
    },
    {
      "name": "Albert R. La Spada",
      "orcid": "0000-0001-6151-2964"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9k4qyfyyg4hs0.bib",
  "cited_by": 0,
  "doi": "10.1016/j.celrep.2026.118128",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2211124726012076",
  "id": "9k4qyfyyg4hs0",
  "issns": [
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  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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  "pmcid": null,
  "pmid": null,
  "published": "2026-10-30",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/9k4qyfyyg4hs0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:34Z",
      "native_id": "10.1016/j.celrep.2026.118128",
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      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2211124726012076"
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    {
      "first_seen": "2026-10-31T14:22:44Z",
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      "url": "https://doi.org/10.1016/j.celrep.2026.118128"
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  "subjects": [
    {
      "field": "biology",
      "origin": "lcc:QH301-705.5",
      "subfield": "general"
    }
  ],
  "title": "Ataxin-2 loss flips a metabolic switch for neuron health",
  "title_text": "Ataxin-2 loss flips a metabolic switch for neuron health",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T14:20:43Z",
  "url": "https://research.draconitic.com/paper/9k4qyfyyg4hs0",
  "venue": "Cell Reports",
  "versions": []
}