{
  "abstract": "Antigen-recognition histories accumulate across adult life, but existing human aging resources largely emphasize host-state measurements rather than antigen-resolved humoral memory. We present CHAIR, the Chinese Healthy Aging Immune Resource, which integrates self-antigen, human virome and toxin/virulence-factor PhIP-seq with routine clinical measurements and T/B/NK phenotyping in clinically screened adults aged 20-94 years. The resource framework includes 1,008 unique PhIP-seq samples, 995 clinical records, 977 T/B/NK records and 853 participants with all three layers. Across modeled spaces comprising 23,584 self-antigen targets, 210 virome targets and 1,258 virulence-factor source targets, most measured antibody-reactivity architecture was consistent with broad preservation within domains, whereas age- and sex-associated signals were concentrated in focal targets and modules. Together, CHAIR provides a traceable, antigen-resolved reference framework based on clinically screened adults for investigating focal humoral remodeling across healthy adult aging.",
  "abstract_shown": true,
  "affiliations": [
    "Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine, Ministry of Education, Tong Ren Hospital, Shanghai Jiao Tong University, Shangha"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "name": "G. N. Sundell"
    },
    {
      "name": "M. Chen"
    },
    {
      "name": "Z. Sha"
    },
    {
      "name": "X. Sun"
    },
    {
      "name": "J. Yao"
    },
    {
      "name": "J. Liu"
    },
    {
      "name": "C. Hu"
    },
    {
      "name": "H. Xu"
    },
    {
      "name": "J. Dai"
    },
    {
      "name": "H. Qi"
    },
    {
      "name": "M. Ma"
    },
    {
      "name": "J. Wu"
    },
    {
      "name": "Y. Li"
    },
    {
      "name": "S. Guo"
    },
    {
      "name": "J. Lin"
    },
    {
      "name": "H. Sheng"
    },
    {
      "affs": [
        0
      ],
      "name": "S.-C. Tao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9kngpp1a24k85.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.29.755197",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.29.755197v1.full",
  "id": "9kngpp1a24k85",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.29.755197v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "immunology"
    ],
    [
      "openalex",
      "2741|Monoclonal and Polyclonal Antibodies Research"
    ]
  ],
  "openalex": "W7154764790",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.29.755197v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9kngpp1a24k85.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:25:57Z",
      "native_id": "10.64898/2026.09.29.755197",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.29.755197v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:immunology",
      "subfield": "immunology"
    }
  ],
  "title": "CHAIR an antigen-resolved antibody-reactome resource for healthy adult immune aging",
  "title_text": "CHAIR an antigen-resolved antibody-reactome resource for healthy adult immune aging",
  "type": "preprint",
  "updated_at": "2026-10-30T12:25:57Z",
  "url": "https://research.draconitic.com/paper/9kngpp1a24k85",
  "venue": "bioRxiv",
  "versions": []
}