{
  "abstract": "Acute myeloid leukemia (AML) is an aggressive clonal myeloid malignancy characterized by the expansion of differentiation-arrested blasts. Treatment resistance, measurable residual disease, and relapse remain major causes of treatment failure. Experimental and clinical evidence indicates that the bone marrow microenvironment can protect heterogeneous AML-cell populations and can also sustain functionally defined or stem-enriched leukemic stem cell (LSC) populations through partly overlapping but non-identical mechanisms. Under physiological conditions, stromal, vascular, neural, and immune components coordinate hematopoietic stem-cell quiescence, retention, and regeneration. In AML, bulk leukemia cells remodel stromal, vascular, extracellular-matrix, metabolic, and immune compartments, whereas LSC-focused studies specifically implicate niche-dependent homing, quiescence, self-renewal, and persistence. This review therefore distinguishes evidence obtained in bulk AML cells from evidence obtained in functionally defined or stem-enriched LSC populations, compares conserved and disease-specific remodeling programs, and summarizes niche-directed therapeutic strategies.",
  "abstract_shown": true,
  "affiliations": [
    "Shandong Second Medical University",
    "Jinan Central Hospital"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Wenhao Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Qing Han"
    },
    {
      "affs": [
        0
      ],
      "name": "Changrong Sun"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Daqi Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9m20g1yxmtgmq.bib",
  "cited_by": 0,
  "doi": "10.3389/fonc.2026.1903019",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13725104/?tool=EBI",
  "id": "9m20g1yxmtgmq",
  "issns": [
    "2234-943X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1903019/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2720|Acute Myeloid Leukemia Research"
    ]
  ],
  "openalex": "W7222919149",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13725104/pdf/?tool=EBI",
  "pmcid": "PMC13725104",
  "pmid": "42974033",
  "published": "2026-10-19",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/9m20g1yxmtgmq.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:13Z",
      "native_id": "10.3389/fonc.2026.1903019",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1903019/full"
    },
    {
      "first_seen": "2026-11-03T15:20:51Z",
      "native_id": "PMC:PMC13725104",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13725104"
    },
    {
      "first_seen": "2026-11-04T12:23:33Z",
      "native_id": "PMC13725104",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fonc.2026.1903019"
    },
    {
      "first_seen": "2026-11-04T15:20:48Z",
      "native_id": "MED:42974033",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42974033"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:2234-943X",
      "subfield": "oncology"
    }
  ],
  "title": "Malignant remodeling of the bone marrow microenvironment in acute myeloid leukemia: mechanisms and therapeutic implications",
  "title_text": "Malignant remodeling of the bone marrow microenvironment in acute myeloid leukemia: mechanisms and therapeutic implications",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:27Z",
  "url": "https://research.draconitic.com/paper/9m20g1yxmtgmq",
  "venue": "Frontiers in Oncology",
  "versions": []
}