{
  "abstract": "Background: Gastroesophageal reflux cough (GERC) is recognized as one of the leading etiologies of chronic cough. However, traditional diagnostic modalities suffer from exceptionally high misdiagnosis rates. This situation frequently puts clinicians in a dilemma of relying on empirical therapeutic trials.\n\nMethods: Integrated with the 2024 Lyon Consensus 2.0, this review aims to explore the crucial value of 24-hour multichannel intraluminal impedance-pH (MII-pH) monitoring in the precision diagnosis of GERC.\n\nMain findings: This review first clarifies the fundamental role of exclusionary broad-spectrum screening and non-invasive initial assessments in early clinical triage. Then, it provides a deep analysis of the dual physical-chemical monitoring theories of MII-pH, systematically explains the four main index of this inspection method. Furthermore, by integrating High-Resolution Manometry (HRM) and oropharyngeal pH monitoring (Restech), this review to construct an individualized, stepwise clinical diagnostic pathway. In the end, this review lists the limitation of MII-pH,provokes the future outlook.\n\nConclusions: MII-pH monitoring plays a critical role in the diagnosis of GERC. It provides assessment of reflux events and reflux-cough associations. Combined with other diagnostic tools, it improves the diagnostic accuracy and provides support for clinical decision making. Despite its limitations, in the future, with the development of technology, MII-pH shall be more valuable in the diagnosis of GERC.",
  "abstract_shown": true,
  "affiliations": [
    "Laboratory of Cough, Affiliated Kunshan Hospital of Jiangsu University, Kunshan Key Laboratory of Chronic Cough, Suzhou, China",
    "Department of Respiratory Medicine, Zhongda Hospital, Southeast University, Nanjing, China",
    "Department of Respiratory Medicine, Taizhou Second People’s Hospital Affiliated to Yangzhou University, Taizhou, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Chang Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Qun Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Lei Pan"
    },
    {
      "affs": [
        0
      ],
      "name": "Changwen Chen"
    },
    {
      "affs": [
        2
      ],
      "name": "Gaoyan Zhai"
    },
    {
      "affs": [
        2
      ],
      "name": "Qiufang Shen"
    },
    {
      "affs": [
        2
      ],
      "name": "Jiahua Pan"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhe Chen",
      "orcid": "0000-0003-2611-9635"
    },
    {
      "affs": [
        0
      ],
      "name": "Hong Zhu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9m2xx7v55f2py.bib",
  "cited_by": 0,
  "doi": "10.1177/17534666261486681",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13724856/",
  "id": "9m2xx7v55f2py",
  "issns": [
    "1753-4658",
    "1753-4666"
  ],
  "landing_url": "https://doi.org/10.1177/17534666261486681",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research Article"
    ],
    [
      "openalex",
      "2715|Gastroesophageal reflux and treatments"
    ]
  ],
  "openalex": "W7213317087",
  "pdf_url": null,
  "pmcid": "PMC13724856",
  "pmid": "42745699",
  "published": "2026-09-16",
  "publisher": "SAGE Publications",
  "ris": "https://research.draconitic.com/paper/9m2xx7v55f2py.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:21Z",
      "native_id": "PMC13724856",
      "source": "pmc",
      "url": "https://doi.org/10.1177/17534666261486681"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2715|Gastroesophageal reflux and treatments",
      "subfield": "general"
    }
  ],
  "title": "Diagnostic pathways for gastroesophageal reflux cough: From empirical recognition to MII-pH-based multidimensional assessment",
  "title_text": "Diagnostic pathways for gastroesophageal reflux cough: From empirical recognition to MII-pH-based multidimensional assessment",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:14Z",
  "url": "https://research.draconitic.com/paper/9m2xx7v55f2py",
  "venue": "Therapeutic Advances in Respiratory Disease",
  "versions": []
}