{
  "abstract": "Drug-resistant bacterium-infected wounds pose a serious clinical challenge, underscoring the need for therapeutic materials that respond to dynamic healing stages. Herein, we report a sequential multimodal platform embedding a self-adaptive IrPtCu nanozyme into a madecassoside-enriched hyaluronic acid hydrogel (HIPCM) for rapid bacterial eradication and accelerated wound healing. Leveraging trimetallic synergy and pH-adaptive reactive oxygen species (ROS) regulation, IrPtCu nanozyme exhibits strong oxidase, peroxidase, glutathione oxidase, and glutathione peroxidase-like activities, enabling efficient ROS generation and potent antibacterial performance. After disinfection, it switches to ROS scavenging through superoxide dismutase and catalase-like cascades, alleviating oxidative stress and cooperating with madecassoside to promote tissue repair. In a methicillin-resistant Staphylococcus aureus (MRSA)-infected mouse model, HIPCM demonstrates strong antibacterial efficacy, promotes M2 macrophage polarization and angiogenesis, and accelerates high-quality repair. Preclinical studies in Bama mini-pigs further confirm improved collagen deposition, hair follicle regeneration, and functional restoration. This work offers a comprehensive strategy integrating adaptive nanozymes and natural herbal medicines for treating drug-resistant wounds.",
  "abstract_shown": true,
  "affiliations": [
    "Academy of Military Medical Sciences, Beijing, China",
    "CAS Engineering Laboratory for Nanozyme, Key Laboratory of Biomacromolecules (CAS), CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China",
    "Academy of Military Medical Sciences, Beijing, China. wangquan0220@126.com",
    "CAS Engineering Laboratory for Nanozyme, Key Laboratory of Biomacromolecules (CAS), CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. fankelong@ibp.ac.cn",
    "Academy of Military Medical Sciences, Beijing, China. zhouhtt1966@163.com",
    "Academy of Military Medical Sciences, Beijing, China. chenlzu2005@163.com"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xiaoyong Zhang",
      "orcid": "0000-0003-1731-1887"
    },
    {
      "affs": [
        0
      ],
      "name": "Hang Yu",
      "orcid": "0009-0008-4889-5348"
    },
    {
      "affs": [
        0
      ],
      "name": "Kai Zhu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yao Xiao",
      "orcid": "0009-0009-4567-9866"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuxuan Gong",
      "orcid": "0000-0003-0609-7635"
    },
    {
      "affs": [
        0
      ],
      "name": "Dandan Che"
    },
    {
      "affs": [
        0
      ],
      "name": "Wanyi Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Guoxing You"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiyun Yan",
      "orcid": "0000-0002-7290-352X"
    },
    {
      "affs": [
        2
      ],
      "name": "Quan Wang",
      "orcid": "0009-0001-3298-2251"
    },
    {
      "affs": [
        3
      ],
      "name": "Kelong Fan",
      "orcid": "0000-0001-6285-1933"
    },
    {
      "affs": [
        4
      ],
      "name": "Hong Zhou"
    },
    {
      "affs": [
        5
      ],
      "name": "Gan Chen",
      "orcid": "0000-0003-4586-4526"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9m8qb6jykbg0d.bib",
  "cited_by": 10,
  "doi": "10.1038/s41467-026-73672-2",
  "fulltext_url": null,
  "id": "9m8qb6jykbg0d",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://doi.org/10.1038/s41467-026-73672-2",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2505|Advanced Nanomaterials in Catalysis"
    ]
  ],
  "openalex": "W7162673263",
  "pdf_url": null,
  "pmcid": "PMC13389173",
  "pmid": "42209494",
  "published": "2026-05-28",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/9m8qb6jykbg0d.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:27:00Z",
      "native_id": "W7162673263",
      "source": "openalex",
      "url": "https://doi.org/10.1038/s41467-026-73672-2"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2505|Advanced Nanomaterials in Catalysis",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Self-adaptive nanozymes with enhanced multi-enzyme activities for sequential multimodal therapy of drug-resistant bacteria-infected wounds",
  "title_text": "Self-adaptive nanozymes with enhanced multi-enzyme activities for sequential multimodal therapy of drug-resistant bacteria-infected wounds",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:22Z",
  "url": "https://research.draconitic.com/paper/9m8qb6jykbg0d",
  "venue": "Nature Communications",
  "versions": []
}