{
  "abstract": "Background/Objectives: Non-muscle-invasive bladder cancer (NMIBC) recurs frequently, and clinicopathological tools predict recurrence imperfectly. We assessed whether six preoperative blood-count-derived inflammatory indices (SII, SIRI, PIV, NLR, PLR, and LMR) are associated with adverse histology and 12-month recurrence and whether SIRI adds prognostic information to established risk factors. Methods: We retrospectively analysed 180 consecutive NMIBC patients treated by transurethral resection of bladder tumour (TURBT) and immediate instillation. Indices were modelled per 1-SD in logistic (adverse histology: high grade, T1 or carcinoma in situ) and Cox (recurrence) models adjusted for established risk factors. Results: Adverse histology occurred in 121 patients (67.2%); 88 recurred (12-month Kaplan–Meier estimate: 49.2%). All six indices were univariably associated with both endpoints, with similar effects (SIRI: adverse histology OR: 2.35, 95% CI: 1.41–3.90; recurrence HR: 1.41, 1.19–1.67). After adjustment, SIRI was not independently associated with adverse histology (OR: 1.69, 0.92–3.11) or recurrence (HR: 1.10, 0.86–1.40) and did not improve discrimination (ΔC: 0.001, −0.006 to 0.016). Results were robust across sensitivity analyses, including propensity weighting for BCG (limited by positivity violations). Conclusions: SIRI added no demonstrable independent prognostic value. Given modest overfitting (optimism-corrected calibration slope: 0.79), neither the indices nor the model should be used clinically without external validation and recalibration.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Urology, University of Medicine and Pharmacy of Craiova, 2 Petru Rareș Street, 200349 Craiova, Romania",
    "Department of Dermatology, University of Medicine and Pharmacy of Craiova, 2 Petru Rareș Street, 200349 Craiova, Romania",
    "Department of Urology, County Emergency Hospital of Târgu-Jiu, 18 Progresului Street, 210218 Târgu-Jiu, Romania",
    "Department of Surgical Oncology, University of Medicine and Pharmacy of Craiova, 2 Petru Rareș Street, 200349 Craiova, Romania",
    "Experimental Research Centre for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, 2 Petru Rareș Street, 200349 Craiova, Romania",
    "Department of Cardiology, University of Medicine and Pharmacy of Craiova, 2 Petru Rareș Street, 200349 Craiova, Romania"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Dragoș Florin Vasile",
      "orcid": "0009-0002-0673-4120"
    },
    {
      "affs": [
        0
      ],
      "name": "Mihnea Meșină"
    },
    {
      "affs": [
        1
      ],
      "name": "George G. Mitroi"
    },
    {
      "affs": [
        2
      ],
      "name": "Alexandru-Daniel Danilă"
    },
    {
      "affs": [
        3
      ],
      "name": "Cosmin Vasile Obleaga"
    },
    {
      "affs": [
        0
      ],
      "name": "Mihai Alexandru Radu",
      "orcid": "0009-0009-1971-8729"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Georgică Târtea"
    },
    {
      "affs": [
        0
      ],
      "name": "George F. Mitroi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9mgw0e4kqs2m4.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15218536",
  "fulltext_url": null,
  "id": "9mgw0e4kqs2m4",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/21/8536",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-02",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/9mgw0e4kqs2m4.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:42Z",
      "native_id": "10.3390/jcm15218536",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/21/8536"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Preoperative Systemic Inflammatory Indices (SII, SIRI and PIV) Associated with Adverse Histology and 12-Month Recurrence After Transurethral Resection of Non-Muscle-Invasive Bladder Cancer",
  "title_text": "Preoperative Systemic Inflammatory Indices (SII, SIRI and PIV) Associated with Adverse Histology and 12-Month Recurrence After Transurethral Resection of Non-Muscle-Invasive Bladder Cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T00:21:25Z",
  "url": "https://research.draconitic.com/paper/9mgw0e4kqs2m4",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}