{
  "abstract": "While genetic heritability plays a major role in the development of cognitive impairment, most genetic risk factors are identified from studies of European populations. We conducted a genome-wide association study (GWAS) on cognitive impairment in the Chinese population by sequencing 1,040 matched case-control individuals from a longitudinal cohort of Zhejiang Province, China. We detected 19 SNPs clustered in 15 genomic loci reaching suggestive significance (P < 1 × 10- 5). Eleven of these genomic loci are newly associated with Alzheimer's disease (AD) or cognitive impairment, among which five (GRP39, FAT1, EDIL3, ZNF596, and PDGFD) show nominal evidence of replication in both external GWAS of AD in East-Asian populations and summary statistics of AD in diverse populations. The detected loci are implicated in micronutrient homeostasis including zinc (GPR39), iron (STEAP1), potassium (KCNJ6), and vitamin K (VKORC1L1), cell connections (EVPLL) through cadherin regulations (PCDH18, FAT1), regulating amyloid-beta precursor protein (APP) (EDIL3), formation of amyloid-β (EDEM1) and neurofibrillary tangles (PDGFD, ZNF596), neuronal growth (NEGR1), and phosphatase regulations (SETBP1, TPTE). This study presents a robust GWAS for cognitive impairment in the Chinese population and highlights a promising set of therapeutic targets for neurodegenerative disorder.",
  "abstract_shown": true,
  "affiliations": [
    "Center for Clinical Research and Biostatistics, JC School of Public Health and Primary Care (JCSPHPC), The Chinese University of Hong Kong (CUHK), Hong Kong SAR, China. maggiew@cuhk.edu.hk.",
    "CUHK Shenzhen Research Institute, No. 10 Yuexing 2nd Road, Shenzhen, 518172, China. maggiew@cuhk.edu.hk.",
    "Beth Bioinformatics Co. Ltd, Hong Kong SAR, China.",
    "School of Medicine, Warshel Institute for Computational Biology, The Chinese University of Hong Kong (CUHK-SZ), 2001 Longxiang Road, Shenzhen, 518172, China.",
    "Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou, 310051, China.",
    "Center for Clinical Research and Biostatistics, JC School of Public Health and Primary Care (JCSPHPC), The Chinese University of Hong Kong (CUHK), Hong Kong SAR, China.",
    "CUHK Shenzhen Research Institute, No. 10 Yuexing 2nd Road, Shenzhen, 518172, China.",
    "Department of Anaesthesia and Intensive Care, CUHK, Hong Kong SAR, China.",
    "Li Ka Shing Institute of Health Sciences, CUHK, Hong Kong SAR, China.",
    "State Key Laboratory of Digestive Diseases, Institute of Digestive Diseases and Department of Medicine and Therapeutics, CUHK, Hong Kong SAR, China.",
    "Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou, 310051, China. jflin@cdc.zj.cn."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Maggie Haitian Wang"
    },
    {
      "affs": [
        2
      ],
      "name": "Yexian Zhang"
    },
    {
      "affs": [
        3
      ],
      "name": "Rui Sun"
    },
    {
      "affs": [
        4
      ],
      "name": "Fudong Li"
    },
    {
      "affs": [
        4
      ],
      "name": "Tao Zhang"
    },
    {
      "affs": [
        4
      ],
      "name": "Xue Gu"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Jingzhi Lou"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Lirong Cao"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Shimin Su"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Hong Zheng"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Caiqi Liu"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Marc Ka Chun Chong"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "William Ka Kei Wu"
    },
    {
      "affs": [
        8,
        9
      ],
      "name": "Jun Yu"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Benny Chung-Ying Zee"
    },
    {
      "affs": [
        10
      ],
      "name": "Junfen Lin"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9mk3f256fw1v2.bib",
  "cited_by": 0,
  "doi": "10.1007/s00439-026-02887-6",
  "fulltext_url": "https://europepmc.org/articles/PMC13675299",
  "id": "9mk3f256fw1v2",
  "issns": [
    "0340-6717",
    "1432-1203"
  ],
  "landing_url": "https://europepmc.org/article/MED/42888346",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
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  "openalex": "W7222850379",
  "pdf_url": "https://europepmc.org/articles/PMC13675299?pdf=render",
  "pmcid": "PMC13675299",
  "pmid": "42888346",
  "published": "2026-10-17",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9mk3f256fw1v2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:46Z",
      "native_id": "MED:42888346",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42888346"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
    }
  ],
  "title": "A genome-wide association study of cognitive impairment in a Chinese cohort of 1,040 individuals.",
  "title_text": "A genome-wide association study of cognitive impairment in a Chinese cohort of 1,040 individuals.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:46Z",
  "url": "https://research.draconitic.com/paper/9mk3f256fw1v2",
  "venue": "Human genetics",
  "versions": []
}