{
  "abstract": "Background: Brain injury, mental health and substance use disorders are leading causes of death and disability worldwide. Despite high rates of comorbidity, it remains unclear how to best support individuals with concurrent brain injury and mental health or substance use problems. The objectives of this study were to: 1) conduct a systematic evidence mapping review on interventions for mental health and substance use in brain injury populations, and 2) develop an interactive user interface to visualize the findings.\n\nMethods: Systematic evidence mapping methodology was used to identify and organize relevant research. PsycINFO, SCOPUS, MEDLINE, the Cochrane Library (CENTRAL and CDSR), Web of Science Core Collection and CINAHL were searched. The AMSTAR-2 was used to evaluate methodological quality and all outcomes are reported according to PRISMA guidelines. Through an iterative prototyping design, the evidence map user interface was developed.\n\nResults: Of the 76,199 records identified, 628 studies involving 815,295 participants with brain injury were included. Records were comprised of 381 impact evaluations, 161 systematic reviews and/or meta-analyses, 39 trial registry records, 43 study protocols and 4 clinical practice guidelines. Most AMSTAR-2 ratings fell within the critically low or low quality range. Cerebrovascular injuries, pharmacological interventions and studies examining depression were among the most researched topics. The development, features and applications of the interactive evidence map are described.\n\nConclusions: Several patterns across the evidence base emerged and evidence gaps were identified, informing priorities for future research. These findings can be used by clinicians to inform treatment planning and by researchers to guide priority areas for future investigations.\n\nSystematic Review Registration: https://doi.org/10.17605/OSF.IO/P64MT",
  "abstract_shown": true,
  "affiliations": [
    "Department of Psychology, University of Victoria, Victoria, BC, Canada",
    "Institute on Aging & Lifelong Health, University of Victoria, Victoria, BC, Canada",
    "Canadian Institute for Substance Use Research, University of Victoria, Victoria, BC, Canada",
    "Department of Computer Science, University of Victoria, Victoria, BC, Canada",
    "Department of Psychology, University of Utah, Salt Lake City, UT, United States",
    "Libraries, University of Victoria, Victoria, BC, Canada",
    "Department of Occupational Science and Occupational Therapy, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada",
    "Rehabilitation Research Program, Centre for Aging SMART, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada",
    "CGB Centre for Traumatic Life Losses, Victoria, BC, Canada",
    "British Columbia Brain Injury Association, Victoria, BC, Canada"
  ],
  "article_type": "systematic review",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Cole J. Kennedy"
    },
    {
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        3
      ],
      "name": "Yichun Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Simon Kurkimaki"
    },
    {
      "affs": [
        0
      ],
      "name": "Nicholas Gavas"
    },
    {
      "affs": [
        4
      ],
      "name": "Emily L. Spargo"
    },
    {
      "affs": [
        0
      ],
      "name": "Bernard Dupriez-Mitchell"
    },
    {
      "affs": [
        0
      ],
      "name": "Devon Rees"
    },
    {
      "affs": [
        5
      ],
      "name": "Zahra Premji"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Erica Woodin"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Julia Schmidt"
    },
    {
      "affs": [
        8,
        9
      ],
      "name": "Janelle Breese Biagioni"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Mauricio A. Garcia-Barrera"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9mmgy90q9n5j2.bib",
  "cited_by": 0,
  "doi": "10.3389/fdgth.2026.1748621",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696407/",
  "id": "9mmgy90q9n5j2",
  "issns": [
    "2673-253X"
  ],
  "landing_url": "https://doi.org/10.3389/fdgth.2026.1748621",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Systematic Review"
    ],
    [
      "openalex",
      "2713|Traumatic Brain Injury Research"
    ]
  ],
  "openalex": "W7221520552",
  "pdf_url": "https://europepmc.org/articles/PMC13696407?pdf=render",
  "pmcid": "PMC13696407",
  "pmid": "42935562",
  "published": "2026-10-12",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/9mmgy90q9n5j2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:46Z",
      "native_id": "PMC13696407",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fdgth.2026.1748621"
    },
    {
      "first_seen": "2026-10-30T12:22:12Z",
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      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42935562"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Traumatic Brain Injury Research",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Interventions for mental health and substance use in brain injury populations: systematic evidence map and review with interactive data visualization",
  "title_text": "Interventions for mental health and substance use in brain injury populations: systematic evidence map and review with interactive data visualization",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:33:45Z",
  "url": "https://research.draconitic.com/paper/9mmgy90q9n5j2",
  "venue": "Frontiers in Digital Health",
  "versions": []
}