{
  "abstract": "Purpose\n\nChemotherapy-induced peripheral neuropathy (CIPN) is common and persistent, with limited management options. This trial primarily examines whether auricular point acupressure (APA) improved CIPN outcomes versus usual care; a secondary pragmatic aim compared in-person mobile support (mAPA) with virtual (vAPA) delivery.Methods\n\nTwo hundred twenty-seven cancer survivors with CIPN were randomized to mAPA (n = 80), vAPA (n = 75), or usual care (n = 72). Both APA arms received the same 4-week auricular point protocol; mAPA received in-person seed placement, and vAPA received video instruction for self-placement, with one coaching session for both. Usual care was standard oncologic and supportive care with no study-delivered APA. Primary outcome was a ≥20% reduction from baseline in an individualized composite outcome (ICO); each participant's highest-rated symptom-by-location item at baseline. Secondary outcomes were neuropathy interference, functional status, and quality of life. Intention-to-treat analyses used generalized estimating equations with multiple imputation and delta-adjusted sensitivity analyses.Results\n\nAt Week 1, both APA arms exceeded usual care (mAPA OR = 2.60, 95% CI 1.27-5.33; vAPA OR = 3.22; 95% CI 1.48-7.01; p < 0.01). The mAPA advantage persisted at Week 2 (OR = 2.49, p = 0.02). For neuropathy interference, mAPA benefits exceeded usual care every week (OR = 3.29-4.28, all p < 0.01). Among exploratory domains, anxiety, depression, and pain interference improved only in mAPA.Conclusion\n\nAPA produced a short-lived advantage in CIPN severity and more consistent improvement in interference, specifically with in-person delivery. Findings are preliminary: no blinding or attention control, differential attrition (52% vAPA versus 96% usual care), and exploratory quality-of-life analyses.Trial registration\n\nClinicalTrials.gov, ID NCT04920097 registered on 3 June 2021.",
  "abstract_shown": true,
  "affiliations": [
    "School of Nursing, Johns Hopkins University, 525 North Wolfe Street, Baltimore, MD, 21205, USA. nada.lukkahatai@jhu.edu.",
    "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. nada.lukkahatai@jhu.edu.",
    "School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.",
    "School of Nursing, Johns Hopkins University, 525 North Wolfe Street, Baltimore, MD, 21205, USA.",
    "Cizik School of Nursing, The University of Texas Health Science Center at Houston, Houston, TX, USA.",
    "McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.",
    "Department of Psychiatry and Behavioral Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.",
    "Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.",
    "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.",
    "Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.",
    "Department of Psychology, Ohio University, Athens, OH, USA.",
    "Faculty of Nursing, Mahidol University, Bangkok, Thailand.",
    "Department of Pain Medicine, Division of Anesthesiology, Critical Care & Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.",
    "Department of Nursing, M. D. Anderson Cancer Center, The University of Texas, Houston, TX, USA.",
    "Department of Population Health Science, University of Texas Health Science at San Antonio, San Antonio, TX, USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 23,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Nada Lukkahatai",
      "orcid": "0000-0003-3820-1812"
    },
    {
      "affs": [
        2
      ],
      "name": "Yannuo Jiang"
    },
    {
      "affs": [
        3
      ],
      "name": "Jingyu Zhang"
    },
    {
      "affs": [
        4
      ],
      "name": "Jennifer Kawi"
    },
    {
      "affs": [
        2
      ],
      "name": "Hulin Wu"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Hongyu Wang"
    },
    {
      "affs": [
        6
      ],
      "name": "Claudia M Campbell"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Johannes Thrul"
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    {
      "affs": [
        9
      ],
      "name": "Haris Sair"
    },
    {
      "affs": [
        6,
        10
      ],
      "name": "Katrina R Hamilton"
    },
    {
      "affs": [
        4
      ],
      "name": "Yumin Cho"
    },
    {
      "affs": [
        11
      ],
      "name": "Chitchanok Benjasirisan"
    },
    {
      "affs": [
        12
      ],
      "name": "Salahadin Abdi"
    },
    {
      "affs": [
        13
      ],
      "name": "Eileen D Hacker",
      "orcid": "0000-0001-7477-1156"
    },
    {
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        5
      ],
      "name": "Syed H Jafri"
    },
    {
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        5
      ],
      "name": "Putao Cen"
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    {
      "affs": [
        5
      ],
      "name": "Anneliese Gonzalez"
    },
    {
      "affs": [
        5
      ],
      "name": "Neha Maithel"
    },
    {
      "affs": [
        5
      ],
      "name": "Julie Rowe"
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    {
      "affs": [
        5
      ],
      "name": "Lavanya H Palavalli Parsons"
    },
    {
      "affs": [
        5,
        14
      ],
      "name": "Jessica Jones"
    },
    {
      "affs": [
        4
      ],
      "name": "Constance M Johnson"
    },
    {
      "affs": [
        8
      ],
      "name": "Thomas J Smith"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9mmrywj829f9g.bib",
  "cited_by": 0,
  "doi": "10.1007/s00520-026-11373-8",
  "fulltext_url": "https://europepmc.org/articles/PMC13722634",
  "id": "9mmrywj829f9g",
  "issns": [
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    "1433-7339"
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  "landing_url": "https://europepmc.org/article/MED/42961520",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
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  "native_subjects": [
    [
      "heading",
      "Research"
    ],
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      "openalex",
      "2730|Cancer Treatment and Pharmacology"
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  "pdf_url": "https://europepmc.org/articles/PMC13722634?pdf=render",
  "pmcid": "PMC13722634",
  "pmid": "42961520",
  "published": "2026-10-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9mmrywj829f9g.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T03:21:21Z",
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    {
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      "native_id": "PMC13722634",
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      "url": "https://doi.org/10.1007/s00520-026-11373-8"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Cancer Treatment and Pharmacology",
      "subfield": "oncology"
    }
  ],
  "title": "Auricular point acupressure for chemotherapy-induced peripheral neuropathy: a randomized controlled trial.",
  "title_text": "Auricular point acupressure for chemotherapy-induced peripheral neuropathy: a randomized controlled trial.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:25Z",
  "url": "https://research.draconitic.com/paper/9mmrywj829f9g",
  "venue": "Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer",
  "versions": []
}