{
  "abstract": "A series of magnetic ternary hybrid nanoparticles were synthesized through the chemical integration of superparamagnetic iron oxide nanoparticles (SPIONs), poly (lactic-co-glycolic acid) (PLGA), and lecithin, further functionalized with Pluronic F-127 (PEO-PPO-PEO). The ternary architecture afforded nanoparticles with well-defined spherical morphology, tunable particle sizes (69–166 nm), and high colloidal stability with zeta potentials exceeding −30 mV. Spectroscopic analyses, including FTIR, DSC, XRD and PLM, confirmed the successful incorporation of therapeutic agents within the ternary matrix, revealing their amorphous dispersion and strong intermolecular interactions with the carrier components. Magnetic characterization demonstrated retained superparamagnetic behavior, highlighting the magnetic responsiveness of the ternary system. In vitro studies against paclitaxel-resistant SUM159/TXR triple-negative breast cancer cells showed that the ternary nanoparticles enhanced cellular uptake, induced synergistic G0/G1 and G2/M cell cycle arrest, and promoted early-stage apoptosis. Co-encapsulation of psoralen and paclitaxel within the ternary hybrid framework amplified cytotoxic effects compared to individual formulations. In vivo evaluation using a xenograft tumor model confirmed superior tumor growth inhibition and minimal systemic toxicity. These results underscore the chemical design and structural optimization of Pluronic F-127-functionalized magnetic ternary hybrid nanoparticles as a promising strategy to overcome multidrug resistance and enhance therapeutic efficacy in aggressive cancers. This study constructed an Pluronic F-127-functionalized magnetic ternary hybrid delivery system co-loaded with superparamagnetic nanoparticles, PTX and PSO, achieving synergistic effects of magnetic targeting, hemotherapy and drug-resistance reversal, which provides a novel strategy for precise therapy of drug-resistant TNBC.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University",
    "International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China",
    "Guangdong Key Lab of Traditional Chinese Medicine Informatization",
    "International Science and Technology Cooperation Base of Guangdong Province",
    "School of Pharmacy, Jinan University",
    "School of Traditional Chinese Medicine, Jinan University",
    "Department of Chinese Medicine, The First Affiliated Hospital of Jinan University",
    "Research Institute for Physical Chemical Problems of the Belarusian State University",
    "Educational-Scientijfic-Production Republican Unitary Enterprise “UNITEHPROM BSU”",
    "College of Pharmacy, University of Sargodha",
    "Department of Oncology and Hematology, Shenzhen Traditional Chinese Medicine Hospital",
    "Division of Breast Surgery, Department of General Surgery, Shenzhen People’s Hospital (The First Affiliated Hospital, Southern University of Science and Technology; The Second Clinical Medical College, Jinan University)"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
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        1,
        2,
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        4
      ],
      "name": "Qian Liu"
    },
    {
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        2,
        3,
        5
      ],
      "name": "Fengjie Liu"
    },
    {
      "affs": [
        6
      ],
      "name": "Panpan Wang"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Uladzislau E. Aharodnikau"
    },
    {
      "affs": [
        9
      ],
      "name": "Mulazim Hussain Asim"
    },
    {
      "affs": [
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        1,
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        3,
        4
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      "name": "Manling Du"
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    {
      "affs": [
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        3,
        4
      ],
      "name": "Qianwen Li"
    },
    {
      "affs": [
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        2,
        3,
        4
      ],
      "name": "Mengjie Xie"
    },
    {
      "affs": [
        10
      ],
      "name": "Zhenjiang Yang"
    },
    {
      "affs": [
        11
      ],
      "name": "Hong Hu"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Yu Cai"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9mpsn7y75a565.bib",
  "cited_by": 0,
  "doi": "10.3389/fphar.2026.1952492",
  "fulltext_url": null,
  "id": "9mpsn7y75a565",
  "issns": [
    "1663-9812"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1952492/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2502|Nanoparticle-Based Drug Delivery"
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  "openalex": "W7223087625",
  "pdf_url": "https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1952492/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-21",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/9mpsn7y75a565.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:06Z",
      "native_id": "10.3389/fphar.2026.1952492",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1952492/full"
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  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Nanoparticle-Based Drug Delivery",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Pluronic F-127-functionalized magnetic ternary hybrid nanoparticles for co-delivery of paclitaxel and psoralen: a synergistic strategy to overcome multidrug resistance in triple-negative breast cancer",
  "title_text": "Pluronic F-127-functionalized magnetic ternary hybrid nanoparticles for co-delivery of paclitaxel and psoralen: a synergistic strategy to overcome multidrug resistance in triple-negative breast cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:06Z",
  "url": "https://research.draconitic.com/paper/9mpsn7y75a565",
  "venue": "Frontiers in Pharmacology",
  "versions": []
}