{
  "abstract": "Liver transplantation (LT) for alcohol-related liver disease (ArLD) has evolved from a pathway centered on decompensated cirrhosis and prolonged abstinence to one that also encompasses severe alcohol-related hepatitis (sAH) and alcohol-related acute-on-chronic liver failure (ACLF). This change reflects the growing burden of ArLD and evidence that carefully selected patients with acute presentations can achieve excellent post-transplant survival. The traditional six-month abstinence rule has limited value as a stand-alone predictor of harmful post-transplant alcohol use. International guidance increasingly supports individualized multidisciplinary assessment of alcohol use disorder (AUD), psychiatric comorbidity, social vulnerability, insight, and treatment engagement, although listing requirements remain heterogeneous. Abstinence nevertheless remains a disease-modifying intervention that may promote clinical improvement, hepatic recompensation, and delisting in selected candidates. After LT, long-term care should integrate prevention and treatment of harmful alcohol use with surveillance and management of graft-related, cardiometabolic, oncologic, infectious, and other medical complications. This narrative Perspective critically appraises LT for ArLD in 2026 and proposes a phenotype-informed framework integrating medical urgency, dynamic reassessment, alcohol-use biomarkers, and longitudinal transplant–addiction care.",
  "abstract_shown": true,
  "affiliations": [
    "Multivisceral Transplant Unit, Padua University Hospital, Via Giustiniani 2, 35122 Padua, Italy",
    "Department of Surgery, Oncology and Gastroenterology, Padua University, 35122 Padua, Italy",
    "Hepatology and Gastroenterology Unit, ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy",
    "Gastroenterology, Padua University Hospital, 35122 Padua, Italy",
    "Legal Medicine and Toxicology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Padua University, 35122 Padua, Italy",
    "CHU Lille, Lille University, 59037 Lille, France"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Alberto Ferrarese",
      "orcid": "0000-0002-3248-2038"
    },
    {
      "affs": [
        2
      ],
      "name": "Giovanni Perricone",
      "orcid": "0000-0003-3890-5393"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Laura Vivian",
      "orcid": "0009-0007-4318-7206"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Alberto Zanetto",
      "orcid": "0000-0002-6734-7178"
    },
    {
      "affs": [
        4
      ],
      "name": "Guido Viel",
      "orcid": "0000-0002-9769-535X"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Patrizia Burra",
      "orcid": "0000-0002-8791-191X"
    },
    {
      "affs": [
        5
      ],
      "name": "Alexandre Louvet",
      "orcid": "0000-0002-5293-007X"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Giacomo Germani"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9n2fsrp9b1m8p.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15207840",
  "fulltext_url": "https://europepmc.org/articles/PMC13705264",
  "id": "9n2fsrp9b1m8p",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/20/7840",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Organ Transplantation Techniques and Outcomes"
    ]
  ],
  "openalex": "W7221542935",
  "pdf_url": "https://europepmc.org/articles/PMC13705264?pdf=render",
  "pmcid": "PMC13705264",
  "pmid": "42941356",
  "published": "2026-10-11",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/9n2fsrp9b1m8p.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:00Z",
      "native_id": "10.3390/jcm15207840",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/20/7840"
    },
    {
      "first_seen": "2026-10-30T12:22:24Z",
      "native_id": "MED:42941356",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42941356"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Organ Transplantation Techniques and Outcomes",
      "subfield": "surgery"
    }
  ],
  "title": "Liver Transplantation for Alcohol-Related Liver Disease in 2026: Phenotypes, Selection, and Post-Transplant Care",
  "title_text": "Liver Transplantation for Alcohol-Related Liver Disease in 2026: Phenotypes, Selection, and Post-Transplant Care",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:24Z",
  "url": "https://research.draconitic.com/paper/9n2fsrp9b1m8p",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}