{
  "abstract": "Deuterated ALC-0315 was synthesized via two steps from three deuterated precursors. A hydrogen-deuterium (H/D) exchange protocol using a Pt/C catalyst was developed for the key precursor, 1-amino-butanol-d8. SANS study reveals that deuteration significantly increases the contrast match point (CMP) of ALC-0315, allowing for contrast-variation small angle neutron scattering measurements to selectively highlight internal LNP core-shell structure.",
  "abstract_shown": true,
  "affiliations": [
    "Center for Nanophase Materials Sciences, Oak Ridge National Laboratory Oak Ridge Tennessee 37831 USA zhangh1@ornl.gov.",
    "Neutron Scattering Division, Oak Ridge National Laboratory Oak Ridge Tennessee 37831 USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hong-Hai Zhang",
      "orcid": "0000-0003-1413-8847"
    },
    {
      "affs": [
        1
      ],
      "name": "Wellington Leite"
    },
    {
      "affs": [
        1
      ],
      "name": "Sai Venkatesh Pingali",
      "orcid": "0000-0001-7961-4176"
    },
    {
      "affs": [
        0
      ],
      "name": "Brandon Nusser"
    },
    {
      "affs": [
        1
      ],
      "name": "Volker S Urban",
      "orcid": "0000-0002-7962-3408"
    },
    {
      "affs": [
        1
      ],
      "name": "Hugh O'Neill"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9np9av5naj3kj.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra04368b",
  "fulltext_url": "https://europepmc.org/articles/PMC13714720",
  "id": "9np9av5naj3kj",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/MED/42953127",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "3003|Chemical Reactions and Isotopes"
    ]
  ],
  "openalex": "W7224107320",
  "pdf_url": "https://europepmc.org/articles/PMC13714720?pdf=render",
  "pmcid": "PMC13714720",
  "pmid": "42953127",
  "published": "2026-10-28",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/9np9av5naj3kj.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:40Z",
      "native_id": "MED:42953127",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42953127"
    },
    {
      "first_seen": "2026-11-01T12:22:09Z",
      "native_id": "PMC13714720",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6ra04368b"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3003|Chemical Reactions and Isotopes",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Synthesis of deuterated ALC-0315 for contrast variation SANS analysis of lipid nanoparticles.",
  "title_text": "Synthesis of deuterated ALC-0315 for contrast variation SANS analysis of lipid nanoparticles.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:09Z",
  "url": "https://research.draconitic.com/paper/9np9av5naj3kj",
  "venue": "RSC advances",
  "versions": []
}