{
  "abstract": "To encode information efficiently, our perceptual system should detect when situations are unpredictable (that is, informative) and modulate brain dynamics to prepare for encoding. Under uncertainty, there is an increased need to generate predictions about upcoming information, a process that has been proposed to require coordinated activity between the hippocampus and neocortex. Here we show, with direct recordings from the human hippocampus and visual cortex, that after exposure to unpredictable visual stimulus streams, hippocampal ripple activity increases in frequency and duration before stimulus presentation. Prestimulus hippocampal ripples suppress changes in visual cortex gamma activity associated with uncertainty and modulate poststimulus prediction error gamma responses in higher-level visual cortex to surprising stimuli. We reveal a function of hippocampal ripples in facilitating the propagation of visual stimuli based on the expected information gain. These results, therefore, link hippocampal ripples with predictive coding accounts of neuronal message passing and precision-weighted prediction errors, revealing a mechanism relevant for perceptual synthesis and subsequent memory encoding.",
  "abstract_shown": true,
  "affiliations": [
    "Andrew Mayes Centre for Cognitive Neuroscience, University of Manchester, Manchester, UK. darya.frank@manchester.ac.uk",
    "Laboratory for Clinical Neuroscience, Centre for Biomedical Technology, Universidad Politécnica de Madrid, IdISSC, Madrid, Spain. darya.frank@manchester.ac.uk",
    "Department of Experimental Psychology, Complutense University of Madrid, Madrid, Spain",
    "Laboratory for Clinical Neuroscience, Centre for Biomedical Technology, Universidad Politécnica de Madrid, IdISSC, Madrid, Spain",
    "Department of Neurosurgery, University Hospital and University of Zurich, Zurich, Switzerland",
    "Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland",
    "Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany",
    "Brigham & Women's Hospital, Center for Brain Circuit Therapeutics, Boston, MA, USA",
    "Department of Neurosurgery, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA",
    "Swiss Epilepsy Center, Klinik Lengg, Zurich, Switzerland",
    "Epilepsy Unit, Department of Neurology, Hospital Ruber Internacional, Madrid, Spain",
    "Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK",
    "IDG/McGovern Institute for Brain Research, Peking University, Beijing, China. bryan.strange@upm.es",
    "Laboratory for Clinical Neuroscience, Centre for Biomedical Technology, Universidad Politécnica de Madrid, IdISSC, Madrid, Spain. bryan.strange@upm.es"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Darya Frank",
      "orcid": "0000-0001-6081-6755"
    },
    {
      "affs": [
        2
      ],
      "name": "Stephan Moratti",
      "orcid": "0000-0003-0824-8759"
    },
    {
      "affs": [
        3
      ],
      "name": "Robin Hellerstedt",
      "orcid": "0000-0002-6433-4734"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Johannes Sarnthein",
      "orcid": "0000-0001-9141-381X"
    },
    {
      "affs": [
        6
      ],
      "name": "Ningfei Li",
      "orcid": "0000-0003-3315-3591"
    },
    {
      "affs": [
        7,
        8,
        6
      ],
      "name": "Andreas Horn",
      "orcid": "0000-0002-0695-6025"
    },
    {
      "affs": [
        5,
        9
      ],
      "name": "Lukas Imbach",
      "orcid": "0000-0002-6135-8642"
    },
    {
      "affs": [
        4
      ],
      "name": "Lennart Henning Stieglitz",
      "orcid": "0000-0002-3744-5105"
    },
    {
      "affs": [
        10
      ],
      "name": "António Gil‐Nagel",
      "orcid": "0000-0003-4515-0793"
    },
    {
      "affs": [
        10
      ],
      "name": "Rafael Toledano",
      "orcid": "0000-0002-9387-1088"
    },
    {
      "affs": [
        11
      ],
      "name": "Karl John Friston",
      "orcid": "0000-0001-7984-8909"
    },
    {
      "affs": [
        12,
        13
      ],
      "name": "Bryan Andrew Strange",
      "orcid": "0000-0001-6476-4091"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9nqm0emyybrxr.bib",
  "cited_by": 6,
  "doi": "10.1038/s41593-026-02345-6",
  "fulltext_url": null,
  "id": "9nqm0emyybrxr",
  "issns": [
    "1097-6256",
    "1546-1726"
  ],
  "landing_url": "https://doi.org/10.1038/s41593-026-02345-6",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "openalex",
      "2805|Memory and Neural Mechanisms"
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  "pdf_url": "https://www.nature.com/articles/s41593-026-02345-6.pdf",
  "pmcid": "PMC13433285",
  "pmid": "42350816",
  "published": "2026-06-25",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/9nqm0emyybrxr.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T13:21:11Z",
      "native_id": "W7165923216",
      "source": "openalex",
      "url": "https://doi.org/10.1038/s41593-026-02345-6"
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  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2805|Memory and Neural Mechanisms",
      "subfield": "neuroscience"
    }
  ],
  "title": "Human hippocampal ripples tune cortical responses based on predicted uncertainty",
  "title_text": "Human hippocampal ripples tune cortical responses based on predicted uncertainty",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:14Z",
  "url": "https://research.draconitic.com/paper/9nqm0emyybrxr",
  "venue": "Nature Neuroscience",
  "versions": []
}