{
  "abstract": "BACKGROUND: Carbapenem-resistant Acinetobacter baumannii (CRAB) is a priority-1 critical pathogen with limited treatment options and high mortality among intensive care unit (ICU) patients. Italy reports hyperendemic levels, whereas France maintains low prevalence. Understanding cross-border differences is essential to inform infection prevention and control (IPC) and antibiotic stewardship strategies. AIM: We investigated incidence trends of CRAB infections in ICUs across the French-Italian border and assessed structural, organizational, IPC, and stewardship practices to identify factors associated with infection risk. METHODS: We conducted a multi-centre observational study involving ICUs of four cross-border regions (Piemonte, Valle d'Aosta, Auvergne-Rhône-Alpes, and Provence-Alpes-Côte d'Azur). Data on ICU-acquired bloodstream infections (BSI), central-line-associated BSI, pneumonia, and ventilator-associated pneumonia with CRAB isolates were extracted from the GiViTI and Réa-Rézo surveillance systems (2019-2022). A structured survey explored ICU characteristics, IPC, and stewardship practices. Logistic regression analysis was performed to identify factors associated with CRAB infection episodes. RESULTS: Overall, 25 ICUs participated in data collection. Among 24,822 ICU admissions, the proportion of A. baumannii isolates that were carbapenem resistant was 18.75% (95% confidence interval [CI]: 7.97-34.98) in France and 83.56% (95% CI: 80.1-86.63) in Italy. Different approaches to IPC and antibiotic stewardship were highlighted. Structural ICU design, staffing flexibility, and resilient IPC and stewardship practices were associated with lower infection risk. CONCLUSION: The CRAB incidence was substantially higher in Italy than in France. Cross-border harmonization of surveillance and co-ordinated preventive strategies are critical to contain cross-border spread.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 60,
  "authors": [
    {
      "name": "C. Vicentini"
    },
    {
      "name": "R. Bussolino"
    },
    {
      "name": "E. Kuczewski"
    },
    {
      "name": "C. Elias"
    },
    {
      "name": "A. Machut"
    },
    {
      "name": "S. Bettoni"
    },
    {
      "name": "M. Perego"
    },
    {
      "name": "L. Bresciano"
    },
    {
      "name": "L. Ramondetti"
    },
    {
      "name": "A. Friggeri"
    },
    {
      "name": "A. Lepape"
    },
    {
      "name": "C.M. Zotti"
    },
    {
      "name": "S. Finazzi"
    },
    {
      "name": "F. Agostini"
    },
    {
      "name": "L. Argaud"
    },
    {
      "name": "N. Barzaghi"
    },
    {
      "name": "Y. Berrouane"
    },
    {
      "name": "J. Bohé"
    },
    {
      "name": "C. Bolla"
    },
    {
      "name": "V. Bonato"
    },
    {
      "name": "E. Brizio"
    },
    {
      "name": "P. Caironi"
    },
    {
      "name": "V. Chartier"
    },
    {
      "name": "J. Crozon-Clauzel"
    },
    {
      "name": "A.D. Selva"
    },
    {
      "name": "S. Debord-Peguet"
    },
    {
      "name": "G. Dessertaine"
    },
    {
      "name": "S. Di Blasi"
    },
    {
      "name": "F. Di Nardo"
    },
    {
      "name": "G. Fiore"
    },
    {
      "name": "M. Gleize"
    },
    {
      "name": "B. Grisi"
    },
    {
      "name": "S. Gatti"
    },
    {
      "name": "V. Gavinelli"
    },
    {
      "name": "H. Hyvernat"
    },
    {
      "name": "C. Landelle"
    },
    {
      "name": "A.-C. Lukaszewicz"
    },
    {
      "name": "A. Maiello"
    },
    {
      "name": "P. Mardrus"
    },
    {
      "name": "A. Mastroianni"
    },
    {
      "name": "B. Mitola"
    },
    {
      "name": "G.G. Montrucchio"
    },
    {
      "name": "E. Munier-Marion"
    },
    {
      "name": "C. Olivieri"
    },
    {
      "name": "O. Ossola"
    },
    {
      "name": "R. Plattier"
    },
    {
      "name": "C. Pommier"
    },
    {
      "name": "T. Rimmelé"
    },
    {
      "name": "J.-C. Richard"
    },
    {
      "name": "M. Salvatico"
    },
    {
      "name": "P. Selvaggi"
    },
    {
      "name": "D. Silengo"
    },
    {
      "name": "P. Silvaplana"
    },
    {
      "name": "C. Silvestre"
    },
    {
      "name": "P.R. Soldà"
    },
    {
      "name": "P. Toscano"
    },
    {
      "name": "C. Vaccari"
    },
    {
      "name": "V. Venturino"
    },
    {
      "name": "E. Vivier"
    },
    {
      "name": "F. Wallet"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9nrztkf9cwc70.bib",
  "cited_by": 2,
  "doi": "10.1016/j.jhin.2026.01.019",
  "fulltext_url": null,
  "id": "9nrztkf9cwc70",
  "issns": [
    "0195-6701",
    "1532-2939"
  ],
  "landing_url": "https://hal.science/hal-05752002v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.spee"
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    [
      "openalex",
      "1313|Antibiotic Resistance in Bacteria"
    ]
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  "openalex": "W7128298909",
  "pdf_url": "https://www.journalofhospitalinfection.com/article/S0195-6701(26)00040-X/pdf",
  "pmcid": null,
  "pmid": "41655744",
  "published": "2026-09-16",
  "publisher": "WB Saunders",
  "ris": "https://research.draconitic.com/paper/9nrztkf9cwc70.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:35Z",
      "native_id": "hal-05752002",
      "source": "hal",
      "url": "https://hal.science/hal-05752002v1"
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  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
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    {
      "field": "medicine",
      "origin": "hal:1.sdv.spee",
      "subfield": "epidemiology-public-health"
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  ],
  "title": "Carbapenem-resistant Acinetobacter baumannii infections in intensive care units: incidence, infection prevention and control, and antimicrobial stewardship practices in the cross-border region between Italy and France, 2019–2022",
  "title_text": "Carbapenem-resistant Acinetobacter baumannii infections in intensive care units: incidence, infection prevention and control, and antimicrobial stewardship practices in the cross-border region between Italy and France, 2019–2022",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:35Z",
  "url": "https://research.draconitic.com/paper/9nrztkf9cwc70",
  "venue": "Journal of Hospital Infection",
  "versions": []
}