{
  "abstract": "Introduction\n\nPatent ductus arteriosus (PDA) is frequent in preterm newborns and its management remains controversial. The objective was to evaluate the association between pharmacological treatment of PDA and mortality in preterm infants.Methods\n\nRetrospective cohort study. A sample size of 154 patients was estimated. Comparisons were performed using the Chi-square test for qualitative variables, and the Mann-Whitney test for continuous variables. Survival analysis was performed using the Kaplan-Meier curve and log-rank test. Cox regression models were used to estimate Hazard ratios (HR) with 95% confidence intervals (95% CI).Results\n\nA total of 156 patients were included. In the survival analysis, Kaplan-Meier curves showed a lower probability of survival in the treated group.In the Cox proportional hazards model, pharmacological treatment was not independently associated with mortality (HR: 2.25; 95% CI: 0.86-5.88; p = 0.09). Birth weight was independently associated with a lower mortality hazard rate (HR: 0.997; 95% CI: 0.995-0.999; p = 0.020). No significant associations were observed with sepsis.Conclusion\n\nExpectant management was not associated with an increase in morbidity or mortality. The lower survival observed with pharmacological treatment in the unadjusted analyses was not maintained after adjustment.",
  "abstract_shown": true,
  "affiliations": [
    "INSIDE Group Research, School of Medicine, Faculty of Health, Universidad del Valle, Cali, Colombia.",
    "Department of Pediatrics, School of Medicine, Faculty of Health, Universidad del Valle, Cali, Colombia.",
    "Versailles Clinic Cali, Cali, Colombia.",
    "Faculty of Health Sciences, Universidad ICESI, Cali, Colombia."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Javier Torres-Muñoz"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Diana María Pérez Manrique"
    },
    {
      "affs": [
        1
      ],
      "name": "Lesly Georjany Escobar Gordillo"
    },
    {
      "affs": [
        0
      ],
      "name": "Angie Marcela Guapacha Alomia"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Julián Torres-Figueroa"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9nssjasnb0rv5.bib",
  "cited_by": 0,
  "doi": "10.3389/fped.2026.1952588",
  "fulltext_url": "https://europepmc.org/articles/PMC13687342",
  "id": "9nssjasnb0rv5",
  "issns": [
    "2296-2360"
  ],
  "landing_url": "https://europepmc.org/article/MED/42923308",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2741|Cardiovascular Conditions and Treatments"
    ]
  ],
  "openalex": "W7220914428",
  "pdf_url": "https://europepmc.org/articles/PMC13687342?pdf=render",
  "pmcid": "PMC13687342",
  "pmid": "42923308",
  "published": "2026-10-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9nssjasnb0rv5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:36Z",
      "native_id": "MED:42923308",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42923308"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Cardiovascular Conditions and Treatments",
      "subfield": "imaging"
    }
  ],
  "title": "Mortality and clinical outcomes in preterm infants with patent ductus arteriosus according to pharmacological treatment or expectant management: a retrospective cohort study.",
  "title_text": "Mortality and clinical outcomes in preterm infants with patent ductus arteriosus according to pharmacological treatment or expectant management: a retrospective cohort study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:36Z",
  "url": "https://research.draconitic.com/paper/9nssjasnb0rv5",
  "venue": "Frontiers in pediatrics",
  "versions": []
}