{
  "abstract": "Background: Reoperation for recurrent glioma is widely practiced, yet clinical decision-making remains challenging due to substantial trade-offs between survival gain and postoperative functional burden. High-quality real-world evidence integrating survival and quality-of-life outcomes to inform reoperation decisions remains limited. Methods: We conducted a retrospective real-world cohort study of 1304 patients with recurrent glioma treated between 2010 and 2018. Propensity score matching was applied to balance baseline characteristics. Survival outcomes, quality-adjusted life years (QALYs), functional status, and prognostic factors associated with reoperation benefit were evaluated. Results: In the 1:1 propensity-matched cohort (140 reoperation vs 140 non-reoperation), reoperation was associated with a mean gain of 9.6 months in quality-adjusted life years (QALYs) and a 521-day longer overall survival. Postoperative functional status showed short-term improvement. In the glioblastoma subgroup, reoperation was associated with a numerical gain of 3.5 QALY months, although the confidence interval crossed zero, alongside a 218-day gain in overall survival. Predictive models based on preoperative characteristics demonstrated good discrimination in identifying patients likely to derive survival benefit beyond 6 months. Conclusion: This study provides real-world evidence that carefully selected patients with recurrent glioma may derive quality-adjusted survival benefits from reoperation, thereby supporting individualized surgical decision-making. These findings have implications for value-based surgical decision-making in recurrent glioma, particularly in healthcare systems where balancing survival benefit against functional outcomes and resource use is increasingly important.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Wanyu Qiao"
    },
    {
      "name": "Chen Luo"
    },
    {
      "name": "Tian Gan"
    },
    {
      "name": "Shuai Wu"
    },
    {
      "name": "Xian Xie"
    },
    {
      "name": "Jinsong Wu"
    },
    {
      "name": "Hugues Duffau"
    },
    {
      "name": "Jie Zhang"
    },
    {
      "name": "Ye Yao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9nwd6j2wazh0n.bib",
  "cited_by": 0,
  "doi": "10.1093/noajnl/vdag251",
  "fulltext_url": null,
  "id": "9nwd6j2wazh0n",
  "issns": [
    "2632-2498"
  ],
  "landing_url": "https://hal.science/hal-05803587v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.scco"
    ],
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.scco.neur"
    ],
    [
      "hal",
      "1.sdv.can"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "hal",
      "2.sdv.mhep.chi"
    ],
    [
      "openalex",
      "2716|Glioma Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7213547698",
  "pdf_url": "https://hal.science/hal-05803587/document",
  "pmcid": null,
  "pmid": "42856975",
  "published": "2026-09-18",
  "publisher": "Society for NeuroOncology (SNO); the European Association of Neuro-Oncology(EANO); and Oxford University Press",
  "ris": "https://research.draconitic.com/paper/9nwd6j2wazh0n.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:58Z",
      "native_id": "hal-05803587",
      "source": "hal",
      "url": "https://hal.science/hal-05803587v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.scco.neur",
      "subfield": "neuroscience"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.can",
      "subfield": "oncology"
    },
    {
      "field": "medicine",
      "origin": "hal:2.sdv.mhep.chi",
      "subfield": "surgery"
    }
  ],
  "title": "Value-based assessment of repeat surgery for recurrent glioma: A real-world quality-adjusted survival analysis",
  "title_text": "Value-based assessment of repeat surgery for recurrent glioma: A real-world quality-adjusted survival analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:58Z",
  "url": "https://research.draconitic.com/paper/9nwd6j2wazh0n",
  "venue": "Neuro-Oncology Advances",
  "versions": []
}