{
  "abstract": "We propose G-EXO, an inverse-designed intrastromal corneal exoskeleton for keratoconus. Unlike conventional intracorneal ring approaches, G-EXO is conceived as a patient-customizable, sectorial and anisotropic scaffold whose geometry and stiffness are optimized to redistribute corneal deformation and reduce asymmetric optical aberrations. We develop a three-dimensional finite-element screening model with localized ectatic weakening, physiological intraocular pressure, and an intrastromal reinforcement domain. A representative design produced a modest but consistent reduction in pressure-induced coma, with a mesh-refined estimate of about 5%, while displacement and stress metrics were more numerically stable. The study is presented as a computational feasibility framework rather than a clinical validation. Its main contribution is to formulate intrastromal reinforcement as a free-form optical-biomechanical inverse-design problem. Patient-specific tomography, nonlinear anisotropic corneal mechanics, full optical modeling, and ex-vivo validation are identified as the next steps.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": "2610.08529",
  "author_total": 2,
  "authors": [
    {
      "name": "J. Sumaya-Martinez"
    },
    {
      "name": "Alan Altamirano"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9p3p7wr5z27zw.bib",
  "cited_by": 0,
  "doi": "10.48550/arxiv.2610.08529",
  "fulltext_url": null,
  "id": "9p3p7wr5z27zw",
  "issns": [],
  "landing_url": "https://arxiv.org/abs/2610.08529",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": "CC0-1.0",
  "native_subjects": [
    [
      "arxiv",
      "physics.bio-ph"
    ],
    [
      "openalex",
      "2741|Corneal surgery and disorders"
    ]
  ],
  "openalex": "W7221030617",
  "pdf_url": "https://arxiv.org/pdf/2610.08529",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-06",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9p3p7wr5z27zw.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:27:22Z",
      "native_id": "2610.08529",
      "source": "arxiv",
      "url": "https://arxiv.org/abs/2610.08529"
    }
  ],
  "subjects": [
    {
      "field": "physics",
      "origin": "arxiv:physics.bio-ph",
      "subfield": "biological-medical"
    }
  ],
  "title": "Inverse-Designed Anisotropic Intrastromal Corneal Exoskeletons for Keratoconus: A Three-Dimensional Computational Feasibility Study",
  "title_text": "Inverse-Designed Anisotropic Intrastromal Corneal Exoskeletons for Keratoconus: A Three-Dimensional Computational Feasibility Study",
  "type": "preprint",
  "updated_at": "2026-10-30T12:27:22Z",
  "url": "https://research.draconitic.com/paper/9p3p7wr5z27zw",
  "venue": "arXiv",
  "versions": []
}