{
  "abstract": "Bloodstream infections (BSI) caused by Escherichia coli and Staphylococcus aureus are frequent and are associated with substantial mortality rate. The host immune response major determinant of the clinical outcomes during BSI. Here, we investigated the innate immune response, by characterizing peripheral blood myeloid cell subsets and caspase-1 activation as a surrogate marker of inflammasome activation in patients with E. coli or S. aureus bacteremia. We prospectively enrolled patients with monomicrobial bacteremia and analyzed peripheral blood samples by flow cytometry. We observed distinct alterations in myeloid cell composition and caspase-1 activation associated with E. coli bacteremia, including an expansion in intermediate and non-classical monocytes, and increased caspase-1 activation in non-classical monocytes. In contrast, these changes were not observed in patients with S. aureus bacteremia. Additionally, we found differences in myeloid cell subset frequencies and caspase-1 activation between patients with and without sepsis, revealing distinct profiles associated with disease severity. Importantly, the differences in myeloid cell subsets and caspase-1 activation between E. coli and S. aureus bacteremia were primarily attributable to the infecting bacteria rather than disease severity. Furthermore, our findings suggest that eosinophil counts, and caspase-1 activation may serve as potential markers to distinguish between bacterial BSI and viral infections. Overall, our study highlights the importance of considering both the infecting pathogen and disease severity when studying the host immune response during bacteremia and suggests that potential innate immune biomarkers may improve the diagnosis and clinical management of BSI.",
  "abstract_shown": true,
  "affiliations": [
    "Inserm, C3M, Université Côte d’Azur, INSERM, C3M, Nice, France",
    "CHU Nice, Université Côte d’Azur, CHU Nice, Nice, France",
    "Réanimation, Centre Hospitalier de Cannes, Cannes, France",
    "Réanimation, Centre Hospitalier d’Antibes, Antibes, France",
    "Pediatrics, Harvard Medical School, Boston, MA, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 24,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Johan Courjon",
      "orcid": "0000-0002-0445-5104"
    },
    {
      "affs": [
        0
      ],
      "name": "Renaud Scussel"
    },
    {
      "affs": [
        0
      ],
      "name": "Eva Mellan"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Romain Lotte"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Raymond Ruimy"
    },
    {
      "affs": [
        1
      ],
      "name": "Elisa Demonchy"
    },
    {
      "affs": [
        1
      ],
      "name": "Karine Risso"
    },
    {
      "affs": [
        1
      ],
      "name": "Irit Touitou"
    },
    {
      "affs": [
        2
      ],
      "name": "Pierre-Marie Bertrand"
    },
    {
      "affs": [
        3
      ],
      "name": "Philippe de Swart"
    },
    {
      "affs": [
        1
      ],
      "name": "Alexandre Robert"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Julie Contenti"
    },
    {
      "affs": [
        1
      ],
      "name": "Jean Dellamonica"
    },
    {
      "affs": [
        1
      ],
      "name": "Mathieu Jozwiak"
    },
    {
      "affs": [
        1
      ],
      "name": "Géraldine Gonfrier"
    },
    {
      "affs": [
        0
      ],
      "name": "Patrick Munro"
    },
    {
      "affs": [
        0
      ],
      "name": "Anne Doye"
    },
    {
      "affs": [
        0
      ],
      "name": "Céline Loubatier"
    },
    {
      "affs": [
        0
      ],
      "name": "Orane Visvikis"
    },
    {
      "affs": [
        0
      ],
      "name": "Paul Chaintreuil"
    },
    {
      "affs": [
        0
      ],
      "name": "Arnaud Jacquel"
    },
    {
      "affs": [
        4
      ],
      "name": "Océane Dufies"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Michel Carles"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Laurent Boyer"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9p56kc75xmrbe.bib",
  "cited_by": 0,
  "doi": "10.1080/21505594.2026.2730393",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13733151/",
  "id": "9p56kc75xmrbe",
  "issns": [
    "2150-5594",
    "2150-5608"
  ],
  "landing_url": "https://doi.org/10.1080/21505594.2026.2730393",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2706|Sepsis Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7225052206",
  "pdf_url": "https://www.tandfonline.com/doi/pdf/10.1080/21505594.2026.2730393?needAccess=true",
  "pmcid": "PMC13733151",
  "pmid": "42967233",
  "published": "2026-11-01",
  "publisher": "Taylor & Francis",
  "ris": "https://research.draconitic.com/paper/9p56kc75xmrbe.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:23:00Z",
      "native_id": "PMC13733151",
      "source": "pmc",
      "url": "https://doi.org/10.1080/21505594.2026.2730393"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2706|Sepsis Diagnosis and Treatment",
      "subfield": "general"
    }
  ],
  "title": "Differences in circulating levels of non-classical monocytes and associated caspase 1 activation during Staphylococcus aureus and Escherichia coli bacteremia",
  "title_text": "Differences in circulating levels of non-classical monocytes and associated caspase 1 activation during Staphylococcus aureus and Escherichia coli bacteremia",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:23:00Z",
  "url": "https://research.draconitic.com/paper/9p56kc75xmrbe",
  "venue": "Virulence",
  "versions": []
}