{
  "abstract": "Chronological age alone is an incomplete proxy for the biological heterogeneity of the aging liver. Mitochondrial vulnerability may provide a mechanistic link between biological aging and the loss of hepatic resilience under metabolic, toxic, and ischemic stress. Accumulating multi-omics evidence suggests that hepatic aging is best understood as a set of coordinated pathway-level disturbances rather than through isolated biomarkers. Transcriptomic, proteomic, and metabolomic studies converge on five interrelated biological modules: lipid stress, diminished oxidative reserve, proteostatic strain, inflammatory sensitization, and reduced recovery capacity. These modules are interconnected through impaired mitochondrial metabolic flexibility, redox buffering, organelle crosstalk, and quality-control mechanisms. Age-associated changes may remain partly compensated at baseline but become more apparent during metabolic overload, ischemia-reperfusion injury, cold preservation, or ex vivo machine perfusion. Building on cross-species evidence, this Review organizes current findings into a modular framework and examines how mitochondrial vulnerability may connect physiological liver aging with metabolic and ischemic stress. Transplantation and machine perfusion are discussed as stress-exposed settings for evaluating candidate tissue- and fluid-based readouts. Although most omics-derived signals remain insufficiently validated for clinical decision-making, a mitochondrial-centered interpretation may help prioritize biologically coherent mechanisms and improve the translational study of aging-related liver vulnerability.",
  "abstract_shown": true,
  "affiliations": [
    "School of Medicine, Zhejiang Chinese Medical University , ,",
    "Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University , , ,",
    "Graduate School of Engineering Biology, Korea Advanced Institute of Science and Technology , ,"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hanxi Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Weiwei Lu"
    },
    {
      "affs": [
        0
      ],
      "name": "Kainan Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Rui Fang"
    },
    {
      "affs": [
        2
      ],
      "name": "Sunjae Lee"
    },
    {
      "affs": [
        0
      ],
      "name": "Shi Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhengtao Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9p5ypw6m8va7a.bib",
  "cited_by": 0,
  "doi": "10.3389/fcell.2026.1954948",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13716950/?tool=EBI",
  "id": "9p5ypw6m8va7a",
  "issns": [
    "2296-634X"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13716950",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "1312|Mitochondrial Function and Pathology"
    ]
  ],
  "openalex": "W7222333675",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13716950/pdf/?tool=EBI",
  "pmcid": "PMC13716950",
  "pmid": "42959209",
  "published": "2026-10-15",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/9p5ypw6m8va7a.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:37Z",
      "native_id": "PMC:PMC13716950",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13716950"
    },
    {
      "first_seen": "2026-10-31T12:21:46Z",
      "native_id": "MED:42959209",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42959209"
    },
    {
      "first_seen": "2026-11-02T12:21:21Z",
      "native_id": "PMC13716950",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fcell.2026.1954948"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Mitochondrial Function and Pathology",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Multi-omics perspectives on mitochondrial vulnerability in the aging liver: biological modules and translational implications",
  "title_text": "Multi-omics perspectives on mitochondrial vulnerability in the aging liver: biological modules and translational implications",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:21:21Z",
  "url": "https://research.draconitic.com/paper/9p5ypw6m8va7a",
  "venue": "Frontiers in cell and developmental biology",
  "versions": []
}