{
  "abstract": "Spinal cord injury (SCI) triggers irreversible neurological dysfunction driven by sequential primary and secondary insults, with neuronal death and neuroinflammation as the central pathological determinants. Despite advances in neuroregeneration research, an incomplete understanding of the molecular regulators underlying these processes limits the development of effective SCI treatment strategies. Post-translational modifications (PTMs) function as critical “dynamic molecular switches” that spatiotemporally regulate protein function and signaling cascades, shaping the SCI microenvironment. Emerging evidence suggests that interdependent PTM networks—rather than isolated modifications—regulate the balance between deterioration and repair. This review synthesizes current insights into seven major PTMs implicated in neuronal death and neuroinflammation after SCI, emphasizing their cooperative crosstalk and the methodological challenges in decoding their temporal dynamics. We propose a “spatiotemporally regulated PTM network” framework to guide therapeutic interventions, highlighting multiplex PTM modulation as a promising strategy to enhance neuronal survival, reduce neuroinflammation, and promote functional recovery after SCI. This review deepens the understanding of PTM crosstalk in SCI pathology and provides new perspectives for developing novel PTM detection and clinical therapeutic strategies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Orthopedic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China",
    "Joint Laboratory for Research & Treatment of Spinal Cord Injury in Spinal Deformity, Laboratory for Clinical Medicine, Capital Medical University, Beijing 100069, China",
    "Department of Spinal Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Weishi Liang"
    },
    {
      "affs": [
        1
      ],
      "name": "Chen Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yeqiu Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Duan Sun"
    },
    {
      "affs": [
        1
      ],
      "name": "Xinan Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Peng Yin"
    },
    {
      "affs": [
        2
      ],
      "name": "Bo Han"
    },
    {
      "affs": [
        1
      ],
      "name": "Xianjun Qu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yong Hai"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9q1mbjvyp1kpj.bib",
  "cited_by": 0,
  "doi": "10.1016/j.apsb.2026.08.032",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13729716/?tool=EBI",
  "id": "9q1mbjvyp1kpj",
  "issns": [
    "2211-3835",
    "2211-3843"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13729716",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2728|Spinal Cord Injury Research"
    ]
  ],
  "openalex": "W7204990041",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13729716/pdf/?tool=EBI",
  "pmcid": "PMC13729716",
  "pmid": "42979069",
  "published": "2026-09-02",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/9q1mbjvyp1kpj.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:47Z",
      "native_id": "PMC:PMC13729716",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13729716"
    },
    {
      "first_seen": "2026-11-07T12:22:28Z",
      "native_id": "PMC13729716",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.apsb.2026.08.032"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Spinal Cord Injury Research",
      "subfield": "neurology"
    }
  ],
  "title": "Spatiotemporal crosstalk of post-translational modifications: A therapeutic avenue in spinal cord injury",
  "title_text": "Spatiotemporal crosstalk of post-translational modifications: A therapeutic avenue in spinal cord injury",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:28Z",
  "url": "https://research.draconitic.com/paper/9q1mbjvyp1kpj",
  "venue": "Acta pharmaceutica Sinica. B",
  "versions": []
}