{
  "abstract": "An efficient electrochemical method for the synthesis of functionalized chromenes via selenylation-induced intramolecular cyclization of alkynes is described. Herein, selenylated chromenes are obtained in yields up to 96%, without the need for external oxidants using an undivided cell equipped with carbon electrodes under galvanostatic conditions. Mechanistic investigations support an anodic generation of electrophilic selenium species, followed by intramolecular cyclization. Furthermore, the method encompasses a versatile substrate scope, demonstrates efficiency on a gram scale, and is significantly improved by using continuous-flow conditions.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, Federal University of São Carlos, São Carlos, São Paulo13565-905, Brazil.",
    "Grupo de Pesquisas em Metodologias Sintéticas (GPMS), Chemistry Department, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais36036-900, Brazil.",
    "Department of Chemistry, State University of Santa Catarina, Joinville, Santa Catarina89219-719, Brazil.",
    "Instituto de Química de São Carlos, Universidade de São Paulo, CP 780, São Carlos, SP13560-970, Brazil."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Guilherme M Martins",
      "orcid": "0000-0002-0493-1270"
    },
    {
      "affs": [
        0
      ],
      "name": "Felipe de Lucca"
    },
    {
      "affs": [
        1
      ],
      "name": "João P R S Ribeiro"
    },
    {
      "affs": [
        1
      ],
      "name": "Pedro P de Castro",
      "orcid": "0000-0002-3018-3130"
    },
    {
      "affs": [
        2
      ],
      "name": "Manoella de Lima"
    },
    {
      "affs": [
        2
      ],
      "name": "Samuel R Mendes",
      "orcid": "0000-0002-2388-3008"
    },
    {
      "affs": [
        3
      ],
      "name": "Roberto G S Berlinck",
      "orcid": "0000-0003-0118-2523"
    },
    {
      "affs": [
        0
      ],
      "name": "Kleber T de Oliveira",
      "orcid": "0000-0002-9131-4800"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9q8pqj86qpzw5.bib",
  "cited_by": 0,
  "doi": "10.1021/acs.joc.6c01733",
  "fulltext_url": "https://europepmc.org/articles/PMC13640421",
  "id": "9q8pqj86qpzw5",
  "issns": [
    "0022-3263",
    "1520-6904"
  ],
  "landing_url": "https://europepmc.org/article/MED/42916961",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "3005|Organoselenium and organotellurium chemistry"
    ]
  ],
  "openalex": "W7213669778",
  "pdf_url": "https://europepmc.org/articles/PMC13640421?pdf=render",
  "pmcid": "PMC13640421",
  "pmid": "42916961",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9q8pqj86qpzw5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:36Z",
      "native_id": "MED:42916961",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42916961"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3005|Organoselenium and organotellurium chemistry",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Electrosynthesis of Functionalized Chromenes via Selenylation-Induced Alkynes Cyclization.",
  "title_text": "Electrosynthesis of Functionalized Chromenes via Selenylation-Induced Alkynes Cyclization.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:36Z",
  "url": "https://research.draconitic.com/paper/9q8pqj86qpzw5",
  "venue": "The Journal of organic chemistry",
  "versions": []
}