{
  "abstract": "Objective\n\nWe explored facilitators influencing participation in randomized clinical trials (RCTs) among underrepresented groups in the United States, including Black and Hispanic/Latinx individuals, women, and rural populations.Methods\n\nWe recruited a convenience sample of adults from these underrepresented groups to complete an online survey of multiple-choice and open-ended questions about preferences and motivations for RCT participation. Recruitment occurred May through September 2023.Results\n\nFacilitators included regular communication, minimizing participant burden, building trust, fair compensation, and emphasizing the purpose and value of research.Conclusion\n\nTo improve inclusivity and generalizability, addressing the barriers to RCT participation for underrepresented groups is crucial. Our results point to the importance of designing RCTs that prioritize transparency, clearly define the research objectives, reduce participant burden, and cultivate trust, while ensuring that compensation and logistical support are equitable and reflect participants' time and effort.",
  "abstract_shown": true,
  "affiliations": [
    "Xavier University of Louisiana, New Orleans, Louisiana, United States.",
    "Palliative and Advanced Illness Research (PAIR) Center at the University of Pennsylvania, Philadelphia, PA, United States.",
    "Behavioral Economics to Transform Trial Enrollment Representativeness (BETTER) Center, American Heart Association Strategically Focused Research Network on the Science of Diversity in Clinical Trials, United States.",
    "The University of Georgia, Athens, GA, United States.",
    "Princeton University, Princeton, NJ, United States.",
    "Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.",
    "Leonard Davis Institute of Health Economics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.",
    "Department of Anesthesiology, Columbia University Vagelos College of Physicians and Surgeons, NY, New York, United States.",
    "Center for Health Incentives and Behavioral Economics (CHIBE) at the University of Pennsylvania, Philadelphia, PA, United States.",
    "Department of Medical Ethics and Health Policy, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Josiah Drakes"
    },
    {
      "affs": [
        1,
        2,
        3
      ],
      "name": "Medha Romee Maitra"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Jasmine A Silvestri"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Emma Britez Ferrante"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Dorothy Sheu"
    },
    {
      "affs": [
        1,
        2,
        4
      ],
      "name": "Sebastian Castro"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Adina Lieberman"
    },
    {
      "affs": [
        1,
        2,
        5,
        6
      ],
      "name": "Scott Halpern"
    },
    {
      "affs": [
        7
      ],
      "name": "Meghan Lane-Fall"
    },
    {
      "affs": [
        1,
        2,
        5,
        6
      ],
      "name": "Rachel Kohn"
    },
    {
      "affs": [
        1,
        2,
        8,
        9
      ],
      "name": "Tamar Klaiman"
    },
    {
      "name": "BETTER Center"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9qczcgmmxk4g8.bib",
  "cited_by": 0,
  "doi": "10.1016/j.pmedr.2026.103653",
  "fulltext_url": "https://europepmc.org/articles/PMC13677178",
  "id": "9qczcgmmxk4g8",
  "issns": [
    "2211-3355"
  ],
  "landing_url": "https://europepmc.org/article/MED/42894875",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2739|Ethics in Clinical Research"
    ]
  ],
  "openalex": "W7220925501",
  "pdf_url": "https://europepmc.org/articles/PMC13677178?pdf=render",
  "pmcid": "PMC13677178",
  "pmid": "42894875",
  "published": "2026-10-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9qczcgmmxk4g8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:37Z",
      "native_id": "MED:42894875",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42894875"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Ethics in Clinical Research",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Strategies for recruitment and retention of underrepresented populations in randomized clinical trials in the United States: A mixed-methods study.",
  "title_text": "Strategies for recruitment and retention of underrepresented populations in randomized clinical trials in the United States: A mixed-methods study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:37Z",
  "url": "https://research.draconitic.com/paper/9qczcgmmxk4g8",
  "venue": "Preventive medicine reports",
  "versions": []
}