{
  "abstract": "InterPro (https://www.ebi.ac.uk/interpro) is a freely accessible resource for the classification of protein sequences. It integrates predictive models, known as signatures, from multiple member databases to classify sequences into families and to predict the presence of domains and functionally important sites. The InterPro database provides annotations for hundreds of millions of sequences, ensuring extensive coverage of UniProtKB, the standard repository of protein sequences, and includes mapping to several other major resources, such as Gene Ontology, the Protein Data Bank in Europe (PDBe), and the AlphaFold Protein Structure Database. In this publication we report on the status of InterPro (version 110.0), detailing new developments in the database, its associated web interface, and software. Notable updates include InterPro-N, a deep-learning method that increases sequence coverage of UniProtKB to over 90%; the transition from InterProScan 5 to the completely re-engineered InterProScan 6; the integration of structure-based domain classifications and predicted structures from AlphaFold; a redesigned protein viewer offering a concise summary view; and a new Model Context Protocol (MCP) server that allows AI assistants to query InterPro programmatically. Over the past two years, 9484 new InterPro entries have been created, bringing the total to 54 922. InterPro data, software and tools are freely available.",
  "abstract_shown": true,
  "affiliations": [
    "European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus , Hinxton CB10 1SD ,",
    "Google DeepMind , Europaallee 36, Zürich 8004 ,",
    "Google DeepMind , 14 Rue de Londres, Paris 75009 ,",
    "Google DeepMind , 325 Main Street, Cambridge, MA 02142 ,",
    "National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , Bethesda, MD 20894 ,",
    "Department of Structural and Molecular Biology, University College London , Gower St, Bloomsbury, London WC1E 6BT ,",
    "Department of Biomedical Sciences, University of Padova , Padova 35121 ,",
    "Swiss-Prot Group, Swiss Institute of Bioinformatics, CMU , 1 rue Michel Servet, CH-1211, Geneva 4 ,",
    "Biobyte Solutions GmbH , Bothestr 142, Heidelberg 69126 ,",
    "Department of Population and Public Health Sciences, University of Southern California , Los Angeles, CA 90033 ,",
    "Protein Information Resource, Georgetown University Medical Center , Washington, DC 20007 ,"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 28,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Matthias Blum",
      "orcid": "0000-0001-5773-4724"
    },
    {
      "affs": [
        0
      ],
      "name": "Antonina Andreeva",
      "orcid": "0000-0002-0450-0091"
    },
    {
      "affs": [
        0
      ],
      "name": "Sara Chuguransky",
      "orcid": "0000-0002-0520-0736"
    },
    {
      "affs": [
        0
      ],
      "name": "Laise Cavalcanti Florentino",
      "orcid": "0009-0002-6916-5973"
    },
    {
      "affs": [
        0
      ],
      "name": "Nicole Morveli Flores",
      "orcid": "0000-0003-2496-881X"
    },
    {
      "affs": [
        0
      ],
      "name": "Tiago Grego",
      "orcid": "0000-0002-7946-7062"
    },
    {
      "affs": [
        0
      ],
      "name": "Emma Elizabeth Mary Hobbs",
      "orcid": "0000-0002-8470-4739"
    },
    {
      "affs": [
        0
      ],
      "name": "Beatriz Lazaro Pinto",
      "orcid": "0000-0001-6837-2941"
    },
    {
      "affs": [
        0
      ],
      "name": "Alessandro Polignano",
      "orcid": "0009-0001-3788-7587"
    },
    {
      "affs": [
        1
      ],
      "name": "Laetitia Meng-Papaxanthos",
      "orcid": "0000-0002-0521-621X"
    },
    {
      "affs": [
        2
      ],
      "name": "Felipe Llinares-López"
    },
    {
      "affs": [
        3
      ],
      "name": "Lucy Colwell",
      "orcid": "0000-0003-3148-0337"
    },
    {
      "affs": [
        4
      ],
      "name": "Aron Marchler-Bauer",
      "orcid": "0000-0003-1516-0712"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Nicola Bordin",
      "orcid": "0000-0002-6568-9035"
    },
    {
      "affs": [
        7
      ],
      "name": "Alan Bridge",
      "orcid": "0000-0003-2148-9135"
    },
    {
      "affs": [
        4
      ],
      "name": "Daniel H Haft",
      "orcid": "0000-0001-8101-4938"
    },
    {
      "affs": [
        4
      ],
      "name": "William Klimke"
    },
    {
      "affs": [
        8
      ],
      "name": "Ivica Letunic",
      "orcid": "0000-0003-3560-4288"
    },
    {
      "affs": [
        9
      ],
      "name": "Huaiyu Mi",
      "orcid": "0000-0001-8721-202X"
    },
    {
      "affs": [
        10
      ],
      "name": "Darren A Natale",
      "orcid": "0000-0001-5809-9523"
    },
    {
      "affs": [
        5
      ],
      "name": "Christine A Orengo",
      "orcid": "0000-0002-7141-8936"
    },
    {
      "affs": [
        6
      ],
      "name": "Damiano Piovesan",
      "orcid": "0000-0001-8210-2390"
    },
    {
      "affs": [
        7
      ],
      "name": "Catherine Rivoire",
      "orcid": "0000-0002-5979-8382"
    },
    {
      "affs": [
        7
      ],
      "name": "Christian J A Sigrist",
      "orcid": "0000-0002-4348-0070"
    },
    {
      "affs": [
        7,
        9
      ],
      "name": "Paul D Thomas",
      "orcid": "0000-0002-9074-3507"
    },
    {
      "affs": [
        6
      ],
      "name": "Silvio C E Tosatto",
      "orcid": "0000-0003-4525-7793"
    },
    {
      "affs": [
        10
      ],
      "name": "Cathy H Wu",
      "orcid": "0000-0001-6379-8601"
    },
    {
      "affs": [
        0
      ],
      "name": "Alex Bateman",
      "orcid": "0000-0002-6982-4660"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9qjsz1j31sfc3.bib",
  "cited_by": 0,
  "doi": "10.1093/nar/gkag1114",
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  "id": "9qjsz1j31sfc3",
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  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
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  "pmcid": null,
  "pmid": null,
  "published": "2026-11-02",
  "publisher": "Oxford University Press (OUP)",
  "ris": "https://research.draconitic.com/paper/9qjsz1j31sfc3.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T12:22:55Z",
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  "subjects": [
    {
      "field": "biochemistry",
      "origin": "issn:0305-1048",
      "subfield": "molecular-biology"
    }
  ],
  "title": "InterPro: the protein sequence classification resource in 2027",
  "title_text": "InterPro: the protein sequence classification resource in 2027",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T00:24:33Z",
  "url": "https://research.draconitic.com/paper/9qjsz1j31sfc3",
  "venue": "Nucleic Acids Research",
  "versions": []
}