{
  "abstract": "Human adenovirus (HAdV) is an important respiratory virus in children, but sequence-level evidence for HAdV-related signals in lower respiratory tract samples remains limited. In this study, we analyzed metagenomic next-generation sequencing data from 189 bronchoalveolar lavage fluid (BALF) libraries from pediatric and adult clinical cohorts, including 30 pediatric and 159 adult patients, together with laboratory environmental controls. MEGAN read-level classification was used to screen for Adenoviridae -related signals. HAdV-related contigs were further reviewed, and a BALF-derived HAdV-B-related representative contig was selected for read recruitment and coverage analysis. Phylogenetic trees were reconstructed using penton base, hexon, and fiber protein sequences. Adenoviridae -classified signals were more apparent in pediatric BALF libraries than in adult BALF libraries or environmental controls. Several pediatric BALF libraries showed broad read coverage across the HAdV-B-related representative contig, whereas adult libraries and environmental controls mainly showed low-coverage-breadth signals. Phylogenetic analysis placed BALF-derived penton base, hexon, and fiber sequences within HAdV-B-related lineages. Twenty-seven capsid protein sequences from 12 pediatric samples had best BLASTp matches to references annotated as HAdV-B3 ( n = 23) or HAdV-B7 ( n = 4). These findings provide sequence evidence for HAdV-B-related sequence signals in clinically selected pediatric BALF samples and support further investigation using targeted assays and genome sequencing.",
  "abstract_shown": true,
  "affiliations": [
    "School of Health and Nursing, Wuxi Taihu University , ,",
    "School of Medicine, Jiangsu University , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Chunyan Zhao"
    },
    {
      "affs": [
        1
      ],
      "name": "Jiaheng Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Ping Wu"
    },
    {
      "affs": [
        1
      ],
      "name": "Wen Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Songyi Ning"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9qk49c06wwp7g.bib",
  "cited_by": 0,
  "doi": "10.3389/fpubh.2026.1961482",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13669151/?tool=EBI",
  "id": "9qk49c06wwp7g",
  "issns": [
    "2296-2565"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13669151",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Respiratory viral infections research"
    ]
  ],
  "openalex": "W7215046816",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13669151/pdf/?tool=EBI",
  "pmcid": "PMC13669151",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/9qk49c06wwp7g.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:18Z",
      "native_id": "PMC:PMC13669151",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13669151"
    },
    {
      "first_seen": "2026-10-30T12:20:22Z",
      "native_id": "10.3389/fpubh.2026.1961482",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fpubh.2026.1961482/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Respiratory viral infections research",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Viral metagenomic characterization of HAdV-B-related signals in bronchoalveolar lavage fluid from pediatric and adult clinical cohorts",
  "title_text": "Viral metagenomic characterization of HAdV-B-related signals in bronchoalveolar lavage fluid from pediatric and adult clinical cohorts",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:22Z",
  "url": "https://research.draconitic.com/paper/9qk49c06wwp7g",
  "venue": "Frontiers in public health",
  "versions": []
}